| http://purl.uniprot.org/citations/18829987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18829987 | http://www.w3.org/2000/01/rdf-schema#comment | "CD28 stimulation contributes to activation of the IL-2 promoter by up-regulating the activity of several transcription factors, including nuclear factor kappaB (NF-kappaB)/Rel family members. However, the signal-transducing cascades linking the CD28 molecule and activation of NF-kappaB remain unclear. Protein kinase C (PKC) , CARMA1 and Bcl10 have recently been reported to integrate TCR-mediated NF-kappaB activation. However, since the data in these studies were drawn from experiments in which T cells were usually stimulated with both TCR and CD28, the relative contributions of TCR- and CD28-mediated signals to initiation of the NF-kappaB pathway remain elusive. To examine the role of these molecules in NF-kappaB activation through CD28-mediated stimulation, Bcl10 was over-expressed in Jurkat cells and their NF-kappaB activation by CD28- or TCR-cross-linking was evaluated. We found that CD28 stimulation alone can induce NF-kappaB activation in Bcl10-over-expressing Jurkat cells, whereas TCR stimulation alone has only little effect. In addition, we found that Bcl10-induced NF-kappaB activation through CD28-mediated stimulation could be blocked by the dominant-negative form of PKC or CARMA1. Furthermore, genetic studies revealed that Grb2/Gads binding, but not phosphatidylinositol 3-kinase binding, is important in CD28-mediated NF-kappaB activation. These findings indicate that the PKC-CARMA1-Bcl10 signaling pathway participates in the CD28 co-stimulatory signal independently of the TCR-signaling pathway, which leads us to propose that the activation of the NF-kappaB-signaling pathway via PKC-CARMA1-Bcl10 may be markedly dependent on CD28 stimulation rather than TCR stimulation."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxn108"xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/author | "Abe R."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/author | "Watanabe R."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/author | "Tanabe K."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/author | "Harada Y."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/author | "Kishimoto H."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/author | "Kagaya S."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/author | "Onuki K."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/author | "Inutake Y."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/pages | "1507-1515"xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/title | "CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis."xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/18829987 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18829987 |
| http://purl.uniprot.org/citations/18829987 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18829987 |
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| http://purl.uniprot.org/uniprot/#_B7ZWE5-mappedCitation-18829987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18829987 |
| http://purl.uniprot.org/uniprot/#_F8WGT6-mappedCitation-18829987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18829987 |
| http://purl.uniprot.org/uniprot/#_Q02111-mappedCitation-18829987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18829987 |
| http://purl.uniprot.org/uniprot/#_Q3THY9-mappedCitation-18829987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18829987 |