| http://purl.uniprot.org/citations/18832646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18832646 | http://www.w3.org/2000/01/rdf-schema#comment | "Ceramide engagement in apoptotic pathways has been a topic of controversy. To address this controversy, we tested loss-of-function (lf) mutants of conserved genes of sphingolipid metabolism in Caenorhabditis elegans. Although somatic (developmental) apoptosis was unaffected, ionizing radiation-induced apoptosis of germ cells was obliterated upon inactivation of ceramide synthase and restored upon microinjection of long-chain natural ceramide. Radiation-induced increase in the concentration of ceramide localized to mitochondria and was required for BH3-domain protein EGL-1-mediated displacement of CED-4 (an APAF-1-like protein) from the CED-9 (a Bcl-2 family member)/CED-4 complex, an obligate step in activation of the CED-3 caspase. These studies define CEP-1 (the worm homolog of the tumor suppressor p53)-mediated accumulation of EGL-1 and ceramide synthase-mediated generation of ceramide through parallel pathways that integrate at mitochondrial membranes to regulate stress-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1158111"xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/author | "Deng X."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/author | "Yin X."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/author | "Shaham S."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/author | "Fuks Z."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/author | "Kolesnick R."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/author | "Haimovitz-Friedman A."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/author | "Maurer C.W."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/author | "Lu D.D."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/author | "Allan R."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/pages | "110-115"xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/title | "Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans."xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://purl.uniprot.org/core/volume | "322"xsd:string |
| http://purl.uniprot.org/citations/18832646 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18832646 |
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