| http://purl.uniprot.org/citations/18833003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18833003 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8+ T-cell memory formation has recently been demonstrated to be associated with CD8alphaalpha homodimer expression by T-cells in mice. Up to now, the knowledge about the clinical significance of CD8alphaalpha+ T-cells in humans is limited. We assessed in longitudinally collected blood samples from patients with melanoma, who underwent a peptide-based vaccination, the role of CD8alphaalpha+ T-cells in tumor-specific cellular immune responses. Phenotypic analysis showed that the expression of CD8alphaalpha+ by T-cells was stable over time and associated with a CD45RA+/-CCR7-effector-memory profile. Melan-A/MART-1-specific T-cells were identified in the CD8alphaalpha+ T-cell compartment by tetramer technology. Detection of intracellular cytokine production (interleukin-2, interferon-gamma, and tumor necrosis factor-alpha) upon phorbol 12-myristate 13-acetate-ionomycin stimulation in CD8alphaalpha+ and CD8alphabeta+ T-cells revealed that CD8alphaalpha+ T-cells show a unique cytokine production pattern (tumor necrosis factor-alpha and interferon-gamma production) as compared with CD8alphabeta+ T-cells. T-cell receptor-CDR3 length analysis revealed that Melan-A/MART-1-specific CD8alphaalpha+ T-cells showed a similar T-cell receptor-repertoire as compared with Melan-A/MART-1-specific CD8alphabeta+ T-cells. Our results show that CD8alphaalpha+ T-cells represent a compartment of CD45RA+/-effector-memory cells in the peripheral circulation of patients with melanoma and suggest that CD8alphaalpha T-cells may originate from CD8+ T-cells that have down-regulated the expression of the CD8beta chain. CD8alphaalpha+ and tetramer-specific T-cells may represent a valuable marker to gauge long-term antigen-specific T-cell memory."xsd:string |
| http://purl.uniprot.org/citations/18833003 | http://purl.org/dc/terms/identifier | "doi:10.1097/cji.0b013e31818883a1"xsd:string |
| http://purl.uniprot.org/citations/18833003 | http://purl.uniprot.org/core/author | "Maeurer M.J."xsd:string |
| http://purl.uniprot.org/citations/18833003 | http://purl.uniprot.org/core/author | "Jager E."xsd:string |
| http://purl.uniprot.org/citations/18833003 | http://purl.uniprot.org/core/author | "Magalhaes I."xsd:string |
| http://purl.uniprot.org/citations/18833003 | http://purl.uniprot.org/core/author | "Vudattu N.K."xsd:string |
| http://purl.uniprot.org/citations/18833003 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18833003 | http://purl.uniprot.org/core/name | "J Immunother"xsd:string |
| http://purl.uniprot.org/citations/18833003 | http://purl.uniprot.org/core/pages | "840-848"xsd:string |
| http://purl.uniprot.org/citations/18833003 | http://purl.uniprot.org/core/title | "Tumor antigen-specific T-cells are Present in the CD8alphaalpha+ T-cell effector-memory pool."xsd:string |
| http://purl.uniprot.org/citations/18833003 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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