| http://purl.uniprot.org/citations/18833194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18833194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18833194 | http://www.w3.org/2000/01/rdf-schema#comment | "[URE3] is a prion (infectious protein), a self-propagating amyloid form of Ure2p, a regulator of yeast nitrogen catabolism. We find that overproduction of Btn2p, or its homologue Ypr158 (Cur1p), cures [URE3]. Btn2p is reported to be associated with late endosomes and to affect sorting of several proteins. We find that double deletion of BTN2 and CUR1 stabilizes [URE3] against curing by several agents, produces a remarkable increase in the proportion of strong [URE3] variants arising de novo and an increase in the number of [URE3] prion seeds. Thus, normal levels of Btn2p and Cur1p affect prion generation and propagation. Btn2p-green fluorescent protein (GFP) fusion proteins appear as a single dot located close to the nucleus and the vacuole. During the curing process, those cells having both Ure2p-GFP aggregates and Btn2p-RFP dots display striking colocalization. Btn2p curing requires cell division, and our results suggest that Btn2p is part of a system, reminiscent of the mammalian aggresome, that collects aggregates preventing their efficient distribution to progeny cells."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.198"xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.198"xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/author | "Wickner R.B."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/author | "Wickner R.B."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/author | "Kryndushkin D.S."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/author | "Kryndushkin D.S."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/author | "Shewmaker F."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/author | "Shewmaker F."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/pages | "2725-2735"xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/pages | "2725-2735"xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/title | "Curing of the [URE3] prion by Btn2p, a Batten disease-related protein."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/title | "Curing of the [URE3] prion by Btn2p, a Batten disease-related protein."xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18833194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18833194 |
| http://purl.uniprot.org/citations/18833194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18833194 |
| http://purl.uniprot.org/citations/18833194 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18833194 |
| http://purl.uniprot.org/citations/18833194 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18833194 |