| http://purl.uniprot.org/citations/18835034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18835034 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasminogen activator inhibitor-1 (PAI-1) paradoxically enhances tumor progression and angiogenesis; however, the mechanism supporting this role is not known. Here we provide evidence that PAI-1 is essential to protect endothelial cells (ECs) from FasL-mediated apoptosis. In the absence of host-derived PAI-1, human neuroblastoma cells implanted in PAI-1-deficient mice form smaller and poorly vascularized tumors containing an increased number of apoptotic ECs. We observed that knockdown of PAI-1 in ECs enhances cell-associated plasmin activity and increases spontaneous apoptosis in vitro. We further demonstrate that plasmin cleaves FasL at Arg144-Lys145, releasing a soluble proapoptotic FasL fragment from the surface of ECs. The data provide a mechanism explaining the proangiogenic activity of PAI-1."xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2008.08.012"xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/author | "Martial J.A."xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/author | "Peng H."xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/author | "DeClerck Y.A."xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/author | "Maillard C."xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/author | "Foidart J.M."xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/author | "Noel A."xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/author | "Bajou K."xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/author | "Laug W.E."xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/pages | "324-334"xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/title | "Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/18835034 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18835034 |
| http://purl.uniprot.org/citations/18835034 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18835034 |
| http://purl.uniprot.org/uniprot/P22777#attribution-EC92C7A3267AB9616A7E9DDC1B64CFAE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18835034 |
| http://purl.uniprot.org/uniprot/P05121#attribution-EC92C7A3267AB9616A7E9DDC1B64CFAE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18835034 |
| http://purl.uniprot.org/uniprot/P05121#attribution-F61CB47CD3A617BE663D35F4DC3A0357 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18835034 |
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| http://purl.uniprot.org/uniprot/P00749#attribution-F61CB47CD3A617BE663D35F4DC3A0357 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18835034 |
| http://purl.uniprot.org/uniprot/#_A0A0H3VB22-mappedCitation-18835034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18835034 |
| http://purl.uniprot.org/uniprot/#_D0ESZ5-mappedCitation-18835034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18835034 |