| http://purl.uniprot.org/citations/18836449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18836449 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice carrying the recessive locus for peripheral T cell deficiency (Ptcd) have a block in thymic egress, but the mechanism responsible is undefined. Here we found that Ptcd T cells had an intrinsic migration defect, impaired lymphoid tissue trafficking and irregularly shaped protrusions. Characterization of the Ptcd locus showed a point substitution of lysine for glutamic acid at position 26 in the actin regulator coronin 1A that enhanced its inhibition of the actin regulator Arp2/3 and resulted in its mislocalization from the leading edge of migrating T cells. The discovery of another coronin 1A mutant during an N-ethyl-N-nitrosourea-mutagenesis screen for T cell-lymphopenic mice prompted us to evaluate a T cell-deficient, B cell-sufficient and natural killer cell-sufficient patient with severe combined immunodeficiency, whom we found had mutations in both CORO1A alleles. Our findings establish a function for coronin 1A in T cell egress, identify a surface of coronin involved in Arp2/3 regulation and demonstrate that actin regulation is a biological process defective in human and mouse severe combined immunodeficiency."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1662"xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "An J."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Cyster J.G."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Bear J.E."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Sorensen R.U."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Grigorova I.L."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Goodnow C.C."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Puck J.M."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Paris K."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Roadcap D.W."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Shiow L.R."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Watson S.R."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Foger N."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Jenne C.N."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/author | "Lebet T."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/pages | "1307-1315"xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/title | "The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency."xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/18836449 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18836449 |
| http://purl.uniprot.org/citations/18836449 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18836449 |