| http://purl.uniprot.org/citations/18836529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18836529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18836529 | http://www.w3.org/2000/01/rdf-schema#comment | "The PTEN tumour suppressor encodes a phosphatase, and its daf-18 orthologue in Caenorhabditis elegans negatively regulates the insulin/IGF-1 DAF-2 receptor pathway that influences lifespan in worms and other species. In order to identify new DAF-18 regulated pathways involved in aging, we initiated a candidate RNAi feeding screen for clones that lengthen lifespan. Here, we report that smg-1 inactivation increases average lifespan in a daf-18 dependent manner. Genetic analysis is consistent with SMG-1 acting at least in part in parallel to the canonical DAF-2 receptor pathway, but converging on the transcription factor DAF-16/FOXO. SMG-1 is a serine-threonine kinase which plays a conserved role in nonsense-mediated mRNA decay (NMD) in worms and mammals. In addition, human SMG-1 has also been implicated in the p53-mediated response to genotoxic stress. The effect of smg-1 inactivation on lifespan appears to be unrelated to its NMD function, but requires the p53 tumour suppressor orthologue cep-1. Furthermore, smg-1 inactivation confers a resistance to oxidative stress in a daf-18-, daf-16- and cep-1-dependent manner. We propose that the role of SMG-1 in lifespan regulation is at least partly dependent on its function in oxidative stress resistance. Taken together, our results unveil a novel role for SMG-1 in lifespan regulation."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0003354"xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0003354"xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Billaud M."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Billaud M."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Palladino F."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Palladino F."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Molin L."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Molin L."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Solari F."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Solari F."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Masse I."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Masse I."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Mouchiroud L."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Mouchiroud L."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Vanhems P."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/author | "Vanhems P."xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/pages | "E3354"xsd:string |
| http://purl.uniprot.org/citations/18836529 | http://purl.uniprot.org/core/pages | "E3354"xsd:string |