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| http://purl.uniprot.org/citations/18838128 | http://www.w3.org/2000/01/rdf-schema#comment | "Tousled-like kinase 1 (or protein kinase ubiquitous, PKU-beta/TLK1) is a serine/threonine protein kinase that is implicated in chromatin remodeling, DNA replication and mitosis. RNAi-mediated PKU-beta/TLK1-depleted human cells showed aneuploidy, and immunofluorescence analysis of these cells revealed the unequal segregation of daughter chromosomes. Immunoblots indicated a substantial reduction in the phosphorylation level of Ser19/Thr18 on the myosin II regulatory light chain (MRLC) in PKU-beta/TLK1-depleted cells, with no change in total MRLC protein. To confirm the relationship between mitotic aberration and MRLC dysfunction, we expressed wild type MRLC or DD-MRLC (mimics diphosphorylation; substitution of both Thr18 and Ser19 with aspartate) in PKU-beta/TLK1-depleted cells. DD-MRLC expression dramatically reduced the unequal segregation of chromosomes. Our data suggest that human PKU-beta/TLK1 plays an important role in chromosome integrity via the regulation of myosin II dynamics by phosphorylating MRLC during mitosis."xsd:string |
| http://purl.uniprot.org/citations/18838128 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mrgentox.2008.09.001"xsd:string |
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| http://purl.uniprot.org/citations/18838128 | http://purl.uniprot.org/core/author | "Hashimoto M."xsd:string |
| http://purl.uniprot.org/citations/18838128 | http://purl.uniprot.org/core/author | "Matsui T."xsd:string |
| http://purl.uniprot.org/citations/18838128 | http://purl.uniprot.org/core/author | "Iwabuchi K."xsd:string |
| http://purl.uniprot.org/citations/18838128 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18838128 | http://purl.uniprot.org/core/name | "Mutat Res"xsd:string |
| http://purl.uniprot.org/citations/18838128 | http://purl.uniprot.org/core/pages | "63-67"xsd:string |
| http://purl.uniprot.org/citations/18838128 | http://purl.uniprot.org/core/title | "PKU-beta/TLK1 regulates myosin II activities, and is required for accurate equaled chromosome segregation."xsd:string |
| http://purl.uniprot.org/citations/18838128 | http://purl.uniprot.org/core/volume | "657"xsd:string |
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