Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18838388http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

IL-1 has a central role mediating inflammation and joint destruction in RA. Single nucleotide polymorphisms (SNPs) and haplotype structure in the promoter region can modulate IL-1 function. This study examined the effects of four common promoter SNPs in the IL-1 region on susceptibility and clinical characteristics of RA in British Caucasian patients and assessed the risk of RA by meta-analysis of published studies.

Methods

Using PCR-based methods, 756 RA patients and 625 healthy controls (HCs) were genotyped for IL-1A (-889 C/A, rs17561), IL-1B (-511 A/G, rs16944), IL-1B (-1464 C/G, rs1143623) and IL-1B (-3737 G/A, rs4848306) SNPs. Further meta-analysis was performed for IL-1B (-511 A/G) incorporating 3712 RA patients and 2331 HC from six association studies.

Results

The IL-1B (-1464 C/G) G allele was found to be less common in the RA group [P = 0.01; odds ratio (OR) 1.24; 95% CI 1.04, 1.48]. There was no association between IL-1 SNPs and the presence of HLA-DRB1 shared epitope, RF or clinical characteristics. Meta-analysis revealed statistically significant association between IL-1B (-511 A/G) and RA (P = 0.02; pooled OR 1.13; 95% CI 1.02, 1.26).

Conclusions

There may be a protective effect in RA from the IL-1B (-1464 C/G) G variant. No direct association between the polymorphisms studied and clinical severity characteristics were observed. Further meta-analysis revealed IL-1B (-511 A/G) to be associated with increased susceptibility to RA."xsd:string
http://purl.uniprot.org/citations/18838388http://purl.org/dc/terms/identifier"doi:10.1093/rheumatology/ken374"xsd:string
http://purl.uniprot.org/citations/18838388http://purl.uniprot.org/core/author"Pointon J.J."xsd:string
http://purl.uniprot.org/citations/18838388http://purl.uniprot.org/core/author"Wordsworth B.P."xsd:string
http://purl.uniprot.org/citations/18838388http://purl.uniprot.org/core/author"Harrison P."xsd:string
http://purl.uniprot.org/citations/18838388http://purl.uniprot.org/core/author"Chapman K."xsd:string
http://purl.uniprot.org/citations/18838388http://purl.uniprot.org/core/author"Roddam A."xsd:string
http://purl.uniprot.org/citations/18838388http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18838388http://purl.uniprot.org/core/name"Rheumatology (Oxford)"xsd:string
http://purl.uniprot.org/citations/18838388http://purl.uniprot.org/core/pages"1768-1770"xsd:string
http://purl.uniprot.org/citations/18838388http://purl.uniprot.org/core/title"Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis."xsd:string
http://purl.uniprot.org/citations/18838388http://purl.uniprot.org/core/volume"47"xsd:string
http://purl.uniprot.org/citations/18838388http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18838388
http://purl.uniprot.org/citations/18838388http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18838388
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18838388
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18838388
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18838388
http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18838388
http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18838388
http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18838388
http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18838388
http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18838388
http://purl.uniprot.org/uniprot/#_A0A141AZI4-mappedCitation-18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18838388
http://purl.uniprot.org/uniprot/#_A0A0A0WAE5-mappedCitation-18838388http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18838388
▶