| http://purl.uniprot.org/citations/18842813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18842813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18842813 | http://www.w3.org/2000/01/rdf-schema#comment | "Anteroposterior polarity in early C. elegans embryos is required for the specification of somatic and germline lineages, and is initiated by a sperm-induced reorganization of the cortical cytoskeleton and PAR polarity proteins. Through mechanisms that are not understood, the kinases PAR-1 and PAR-4, and other PAR proteins cause the cytoplasmic zinc finger protein MEX-5 to accumulate asymmetrically in the anterior half of the one-cell embryo. We show that MEX-5 asymmetry requires neither vectorial transport to the anterior, nor protein degradation in the posterior. MEX-5 has a restricted mobility before fertilization and in the anterior of one-cell embryos. However, MEX-5 mobility in the posterior increases as asymmetry develops, presumably allowing accumulation in the anterior. The MEX-5 zinc fingers and a small, C-terminal domain are essential for asymmetry; the zinc fingers restrict MEX-5 mobility, and the C-terminal domain is required for the increase in posterior mobility. We show that a crucial residue in the C-terminus, Ser 458, is phosphorylated in vivo. PAR-1 and PAR-4 kinase activities are required for the phosphorylation of S458, providing a link between PAR polarity proteins and the cytoplasmic asymmetry of MEX-5."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.027060"xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.027060"xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/author | "Page B.D."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/author | "Page B.D."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/author | "London N."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/author | "London N."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/author | "Molk J.N."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/author | "Molk J.N."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/author | "Priess J.R."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/author | "Priess J.R."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/author | "Tenlen J.R."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/author | "Tenlen J.R."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/pages | "3665-3675"xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/pages | "3665-3675"xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/title | "MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/title | "MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/18842813 | http://purl.uniprot.org/core/volume | "135"xsd:string |