| http://purl.uniprot.org/citations/18845640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18845640 | http://www.w3.org/2000/01/rdf-schema#comment | "Steroid hormone synthesis is a vital function of the adrenal cortex, serves a critical role in gonadal function, and maintains pregnancy if normally executed in the placenta. The substrate for the synthesis of all steroid hormones is cholesterol, and its conversion to the first steroid, pregnenolone, by the cholesterol side-chain cleavage cytochrome P450 (CYP11A1) enzyme complex takes place in the inner mitochondrial membranes. Steroidogenic acute regulatory protein (STAR) facilitates the rate-limiting transfer of cholesterol from the outer mitochondrial membrane to CYP11A1 located in the inner organelle membranes. The current study explored the mechanisms controlling transcription of the Star gene in primary cell cultures of mouse placental trophoblast giant cells and rat ovarian granulosa cells examined throughout the course of their functional differentiation. Our findings show that the cis-elements required for Star transcription in the rodent placenta and the ovary are centered in a relatively small proximal region of the promoter. In placental trophoblast giant cells, cAMP is required for activation of the Star promoter, and the cis-elements mediating a maximal response were defined as cAMP response element 2 and GATA. EMSA studies show that placental cAMP-responsive element binding protein (CREB)-1 and activating transcription factor-2 (ATF2) bind to a -81/-78 sequence, whereas GATA-2 binds to a -66/-61 sequence. In comparison, patterns of Star regulation in the ovary suggested tissue-specific and developmental controlled modes of Star transcription. During the follicular phase, FSH/cAMP induced CREB-1 dependent activity, whereas upon luteinization STAR expression becomes cAMP and CREB independent, a functional shift conferred by FOS-related antigen-2 displacement of CREB-1 binding, and the appearance of a new requirement for CCAAT enhancer-binding protein beta and steroidogenic factor 1 that bind to upstream elements (-117/-95). These findings suggest that during evolution, the promoters of the Star gene acquired nonconsensus sequence elements enabling expression of a single gene in different organs, or allowing dynamic temporal changes corresponding to progressing phases of differentiation in a given cell type."xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2008-0541"xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/author | "Orly J."xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/author | "Melamed-Book N."xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/author | "Sher N."xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/author | "Manna P.R."xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/author | "Eimerl S."xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/author | "Yivgi-Ohana N."xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/author | "Stocco D.M."xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/author | "Koler M."xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/pages | "977-989"xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/title | "Transcription of steroidogenic acute regulatory protein in the rodent ovary and placenta: alternative modes of cyclic adenosine 3', 5'-monophosphate dependent and independent regulation."xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://purl.uniprot.org/core/volume | "150"xsd:string |
| http://purl.uniprot.org/citations/18845640 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18845640 |
| http://purl.uniprot.org/citations/18845640 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18845640 |
| http://purl.uniprot.org/uniprot/#_P51557-mappedCitation-18845640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845640 |
| http://purl.uniprot.org/uniprot/#_Q6P910-mappedCitation-18845640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845640 |
| http://purl.uniprot.org/uniprot/Q6P910 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18845640 |
| http://purl.uniprot.org/uniprot/P51557 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18845640 |