| http://purl.uniprot.org/citations/18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18845789 | http://www.w3.org/2000/01/rdf-schema#comment | "Bcl2 is associated with chemoresistance and poor prognosis in patients with various hematologic malignancies. DNA damage-induced p53/Bcl2 interaction at the outer mitochondrial membrane results in a Bcl2 conformational change with loss of its antiapoptotic activity in interleukin-3-dependent myeloid H7 cells. Here we find that specific disruption of protein phosphatase 2A (PP2A) activity by either expression of small t antigen or depletion of PP2A/C by RNA interference enhances Bcl2 phosphorylation and suppresses cisplatin-stimulated p53/Bcl2 binding in association with prolonged cell survival. By contrast, treatment of cells with C2-ceramide (a potent PP2A activator) or expression of the PP2A catalytic subunit (PP2A/C) inhibits Bcl2 phosphorylation, leading to increased p53/Bcl2 binding and apoptotic cell death. Mechanistically, PP2A-mediated dephosphorylation of Bcl2 in vitro promotes its direct interaction with p53 as well as a conformational change in Bcl2. PP2A directly interacts with the BH4 domain of Bcl2 as a docking site to potentially "bridge" PP2A to Bcl2's flexible loop domain containing the target serine 70 phosphorylation site. Thus, PP2A may provide a dual inhibitory effect on Bcl2's survival function by both dephosphorylating Bcl2 and enhancing p53-Bcl2 binding. Activating PP2A to dephosphorylate Bcl2 and/or increase Bcl2/p53 binding may represent an efficient and novel approach for treatment of hematologic malignancies."xsd:string |
| http://purl.uniprot.org/citations/18845789 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-06-165134"xsd:string |
| http://purl.uniprot.org/citations/18845789 | http://purl.uniprot.org/core/author | "Deng X."xsd:string |
| http://purl.uniprot.org/citations/18845789 | http://purl.uniprot.org/core/author | "Gao F."xsd:string |
| http://purl.uniprot.org/citations/18845789 | http://purl.uniprot.org/core/author | "May W.S."xsd:string |
| http://purl.uniprot.org/citations/18845789 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18845789 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18845789 | http://purl.uniprot.org/core/pages | "422-428"xsd:string |
| http://purl.uniprot.org/citations/18845789 | http://purl.uniprot.org/core/title | "Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding."xsd:string |
| http://purl.uniprot.org/citations/18845789 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/18845789 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18845789 |
| http://purl.uniprot.org/citations/18845789 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18845789 |
| http://purl.uniprot.org/uniprot/#_P10415-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_P10417-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_A6YM30-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_A5JTV6-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_G3UWL2-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_G3UXQ1-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_P62715-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_Q7TMX2-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |
| http://purl.uniprot.org/uniprot/#_P02340-mappedCitation-18845789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18845789 |