| http://purl.uniprot.org/citations/18848628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18848628 | http://www.w3.org/2000/01/rdf-schema#comment | "Disabled 1 (Dab1), a cytoplasmic adaptor protein expressed predominantly in the CNS, transduces a Reelin-initiated signaling that controls neuronal migration and positioning during brain development. To determine the role of Dab1 in neural stem cell (NSC) differentiation, we established a culture of neurospheres derived from the embryonic forebrain of the Dab1(-/-) mice, yotari. Differentiating Dab1(-/-) neurospheres exhibited a higher expression of GFAP, an astrocytic marker, at the expense of neuronal markers. Under Dab1-deficient condition, the expression of NeuroD, a transcription factor for neuronal differentiation, was decreased and the JAK-STAT pathway was evidently increased during differentiation of NSC, suggesting the possible involvement of Dab1 in astrocyte differentiation via JAK-STAT pathway. Notably, expression of neural and glial markers and the level of JAK-STAT signaling molecules were not changed in differentiating NSC by Reelin treatment, indicating that differentiation of NSC is Reelin-independent. Immunohistochemical analyses showed a decrease in the number of neurons and an increase in the number of GFAP-positive cells in developing yotari brains. Our results suggest that Dab1 participates in the differentiation of NSCs into a specific cell lineage, thereby maintaining a balance between neurogenesis and gliogenesis."xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2008.08.012"xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/author | "Cho S.K."xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/author | "Mitsuda N."xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/author | "Lee Y.D."xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/author | "Tsai M.J."xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/author | "Kwon I.S."xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/author | "Suh-Kim H."xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/name | "Mol Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/pages | "50-61"xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/title | "Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells."xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/18848628 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18848628 |
| http://purl.uniprot.org/citations/18848628 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18848628 |
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