| http://purl.uniprot.org/citations/18848921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18848921 | http://www.w3.org/2000/01/rdf-schema#comment | "The autonomic nervous system is known to mediate mast cell activation. We investigated expression of nicotinic acetylcholine receptors (nAChRs) in mucosal-type mast cells and their contribution to the regulation of mast cell activation. Expression of mRNA of nAChR alpha4, alpha7, and beta2 subunits were detected in specially differentiated mucosal-type murine bone marrow-derived mast cells (mBMMCs). Pretreatment with non-specific nAChRs agonists, acetylcholine, nicotine and epibatidine and a specific alpha7 subunit agonist GTS-21 significantly inhibited antigen-induced degranulation of mBMMCs in a dose-dependent manner and GTS-21-induced inhibition was significantly blocked by alpha7 subunit antagonist, alpha-bungarotoxin. Furthermore, confocal microscopy also demonstrated surface binding of alpha-bungarotoxin on mBMMCs. Our findings indicate that mucosal mast cell activation may be negatively regulated mainly through nAChR alpha7 subunit, suggesting that nAChRs are involved in neuronal-mucosal mast cell interactions."xsd:string |
| http://purl.uniprot.org/citations/18848921 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.10.004"xsd:string |
| http://purl.uniprot.org/citations/18848921 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/18848921 | http://purl.uniprot.org/core/author | "Kageyama-Yahara N."xsd:string |
| http://purl.uniprot.org/citations/18848921 | http://purl.uniprot.org/core/author | "Kadowaki M."xsd:string |
| http://purl.uniprot.org/citations/18848921 | http://purl.uniprot.org/core/author | "Suehiro Y."xsd:string |
| http://purl.uniprot.org/citations/18848921 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18848921 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/18848921 | http://purl.uniprot.org/core/pages | "321-325"xsd:string |
| http://purl.uniprot.org/citations/18848921 | http://purl.uniprot.org/core/title | "IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors."xsd:string |
| http://purl.uniprot.org/citations/18848921 | http://purl.uniprot.org/core/volume | "377"xsd:string |
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