| http://purl.uniprot.org/citations/18849981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18849981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18849981 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptic proteins are synthesized in the cell body and transported down the axon by microtubule-dependent motors. We previously reported that KIF1Bbeta and KIF1A motors are essential for transporting synaptic vesicle precursors; however the mechanisms that regulate transport, as well as cargo recognition and control of cargo loading and unloading remain largely unknown. Here, we show that DENN/MADD (Rab3-GEP) is an essential part of the regulation mechanism through direct interaction with the stalk domain of KIF1Bbeta and KIF1A. We also show that DENN/MADD binds preferentially to GTP-Rab3 and acts as a Rab3 effector. These molecular interactions are fundamental as sequential genetic perturbations revealed that KIF1Bbeta and KIF1A are essential for the transport of DENN/MADD and Rab3, whereas DENN/MADD is essential for the transport of Rab3. GTP-Rab3 was more effectively transported than GDP-Rab3, suggesting that the nucleotide state of Rab3 regulates axonal transport of Rab3-carrying vesicles through preferential interaction with DENN/MADD."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1785"xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1785"xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/author | "Hirokawa N."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/author | "Hirokawa N."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/author | "Niwa S."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/author | "Niwa S."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/pages | "1269-1279"xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/pages | "1269-1279"xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/title | "KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/title | "KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD."xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/18849981 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18849981 |
| http://purl.uniprot.org/citations/18849981 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18849981 |
| http://purl.uniprot.org/citations/18849981 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18849981 |
| http://purl.uniprot.org/citations/18849981 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18849981 |