| http://purl.uniprot.org/citations/18852059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18852059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18852059 | http://www.w3.org/2000/01/rdf-schema#comment | "Relaxins are peptides similar in secondary structure to insulins. In teleost genomes, five or six relaxin genes have been identified. Two relaxins group closely with mammalian relaxin-3 on phylogenetic analysis and are named relaxin-3a and b. We refer to the remainder as relaxins c to f. Ovarian expression of relaxin-3a, d and f genes, and the relaxin-3 receptor gene Rxfp3, was studied in Danio rerio using RT-PCR. Immunohistochemistry was used to determine the distribution of relaxin-3 peptides and RXFP3 in the ovary of Fundulus heteroclitus (killifish). Thirdly, enzyme immunoassays and ovarian follicular culture were used to determine the effect of treatment with human recombinant relaxin-3 on the production of 17beta-estradiol and 17 alpha, 20 beta-dihydroxy-4-pregnen-3-one in killifish ovarian follicles. Relaxin-3a, d, f, and Rxfp3 genes were expressed regardless of sex or reproductive condition. Relaxin-3 immunostaining was present in mid to late follicular stages within cortical alveoli of the oocyte cytopasm, whereas receptor staining was localized to follicular cells. Treatment with relaxin-3 enhanced 17beta-estradiol production in early and late maturing follicles, but did not have an effect in vitellogenic follicles. Relaxin-3 appeared to suppress the release of MIS production. This suggests that relaxin peptides may be involved with estradiol-dependant events in follicular development."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cbpa.2008.09.020"xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cbpa.2008.09.020"xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/author | "Rappaport R."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/author | "Rappaport R."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/author | "Parry L.J."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/author | "Parry L.J."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/author | "Wilson B.C."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/author | "Wilson B.C."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/author | "Burnett D."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/author | "Burnett D."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/author | "Fletcher E.K."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/author | "Fletcher E.K."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/name | "Comp. Biochem. Physiol., Part A Mol. Integr. Physiol."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/name | "Comp Biochem Physiol A Mol Integr Physiol"xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/pages | "69-74"xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/pages | "69-74"xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/title | "Relaxin-3 and RXFP3 expression, and steroidogenic actions in the ovary of teleost fish."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/title | "Relaxin-3 and RXFP3 expression, and steroidogenic actions in the ovary of teleost fish."xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/volume | "153"xsd:string |
| http://purl.uniprot.org/citations/18852059 | http://purl.uniprot.org/core/volume | "153"xsd:string |