| http://purl.uniprot.org/citations/18854144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18854144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18854144 | http://www.w3.org/2000/01/rdf-schema#comment | "The Aurora B kinase is the enzymatic core of the chromosomal passenger complex, which is a critical regulator of mitosis. To identify novel regulators of Aurora B, we performed a genome-wide screen for suppressors of a temperature-sensitive lethal allele of the C. elegans Aurora B kinase AIR-2. This screen uncovered a member of the Afg2/Spaf subfamily of Cdc48-like AAA ATPases as an essential inhibitor of AIR-2 stability and activity. Depletion of CDC-48.3 restores viability to air-2 mutant embryos and leads to abnormally high AIR-2 levels at the late telophase/G1 transition. Furthermore, CDC-48.3 binds directly to AIR-2 and inhibits its kinase activity from metaphase through telophase. While canonical p97/Cdc48 proteins have been assigned contradictory roles in the regulation of Aurora B, our results identify a member of the Afg2/Spaf AAA ATPases as a critical in vivo inhibitor of this kinase during embryonic development."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2008.08.005"xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2008.08.005"xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/author | "Furuta T."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/author | "Furuta T."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/author | "Schumacher J.M."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/author | "Schumacher J.M."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/author | "Adams H.P."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/author | "Adams H.P."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/author | "Heallen T.R."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/author | "Heallen T.R."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/author | "Verbrugghe K.J."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/author | "Verbrugghe K.J."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/pages | "603-616"xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/pages | "603-616"xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/title | "An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/title | "An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2."xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/18854144 | http://purl.uniprot.org/core/volume | "15"xsd:string |