| http://purl.uniprot.org/citations/18854159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18854159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18854159 | http://www.w3.org/2000/01/rdf-schema#comment | "Stromal interaction molecule-1 (STIM1) activates store-operated Ca2+ entry (SOCE) in response to diminished luminal Ca2+ levels. Here, we present the atomic structure of the Ca2+-sensing region of STIM1 consisting of the EF-hand and sterile alpha motif (SAM) domains (EF-SAM). The canonical EF-hand is paired with a previously unidentified EF-hand. Together, the EF-hand pair mediates mutually indispensable hydrophobic interactions between the EF-hand and SAM domains. Structurally critical mutations in the canonical EF-hand, "hidden" EF-hand, or SAM domain disrupt Ca2+ sensitivity in oligomerization via destabilization of the entire EF-SAM entity. In mammalian cells, EF-SAM destabilization mutations within full-length STIM1 induce punctae formation and activate SOCE independent of luminal Ca2+. We provide atomic resolution insight into the molecular basis for STIM1-mediated SOCE initiation and show that the folded/unfolded state of the Ca2+-sensing region of STIM is crucial to SOCE regulation."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.08.006"xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.08.006"xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/author | "Li G.Y."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/author | "Li G.Y."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/author | "Ikura M."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/author | "Ikura M."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/author | "Plevin M.J."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/author | "Plevin M.J."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/author | "Stathopulos P.B."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/author | "Stathopulos P.B."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/pages | "110-122"xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/pages | "110-122"xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/title | "Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/title | "Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry."xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/18854159 | http://purl.uniprot.org/core/volume | "135"xsd:string |