| http://purl.uniprot.org/citations/18854239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18854239 | http://www.w3.org/2000/01/rdf-schema#comment | "Educating dendritic cells (DC) to become tolerogenic DC, which promote regulatory IL-10 immune responses, represents an effective immune evasion strategy for pathogens. Yersinia pestis virulence factor LcrV is reported to induce IL-10 production via interaction with Toll-like receptor (TLR) 2. However, TLR2-/-mice are not protected against subcutaneous plague infection. Using complementary in vitro and in vivo approaches and LcrV as a model, we show that TLR6 associates with TLR2 to induce tolerogenic DC and regulatory type-1 T cells selectively secreting IL-10. In contrast, TLR1 heterodimerizes with TLR2 to promote proinflammatory IL-12p40 cytokine, producing DC and inflammatory T cell differentiation. LcrV specifically hijacks the TLR2/6 pathway to stimulate IL-10 production, which blocks host protective inflammatory responses. These results explain why TLR2 can mediate both pro- and anti-inflammatory responses and identify TLR6 as a distinct receptor driving regulatory IL-10 responses."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2008.09.004"xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/author | "Anderson D."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/author | "Schneewind O."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/author | "Lin A."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/author | "Kim I."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/author | "Tang F."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/author | "Levin N."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/author | "Jabri B."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/author | "Depaolo R.W."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/author | "Ciletti N."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/name | "Cell Host Microbe"xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/pages | "350-361"xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/title | "Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/18854239 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18854239 |
| http://purl.uniprot.org/citations/18854239 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18854239 |
| http://purl.uniprot.org/uniprot/#_Q0PM14-mappedCitation-18854239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18854239 |
| http://purl.uniprot.org/uniprot/#_Q7TPC5-mappedCitation-18854239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18854239 |
| http://purl.uniprot.org/uniprot/#_G3X8Y8-mappedCitation-18854239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18854239 |
| http://purl.uniprot.org/uniprot/#_Q3UV88-mappedCitation-18854239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18854239 |
| http://purl.uniprot.org/uniprot/#_Q811T5-mappedCitation-18854239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18854239 |