| http://purl.uniprot.org/citations/18854828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18854828 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytosolic sulphotransferase SULT1A1 plays a dual role in the activation of some carcinogens and inactivation of others. A functional polymorphism leading to Arg(213)His substitution (SULT1A1*2) affects its catalytic activity and thermostability. To study the association of SULT1A1*2 polymorphism with tobacco-related cancers (TRCs), a case-control study comprising 132 patients with multiple primary neoplasm (MPN) involving TRC and 198 cancer-free controls was carried out. One hundred and thirteen MPN patients had at least one cancer in upper aerodigestive tract including lung (UADT-MPN). SULT1A1*2 showed significant risk association with UADT-MPN (odds ratio (OR)=5.50, 95% confidence interval (CI): 1.09, 27.7). Meta-analysis was conducted combining the data with 34 published studies that included 11 962 cancer cases and 14 673 controls in diverse cancers. The SULT1A1*2 revealed contrasting risk association for UADT cancers (OR=1.62, 95% CI: 1.12, 2.34) and genitourinary cancers (OR=0.73, 95% CI: 0.58, 0.92). Furthermore, although SULT1A1*2 conferred significant increased risk of breast cancer to Asian women (OR=1.91, 95% CI: 1.08, 3.40), it did not confer increased risk to Caucasian women (OR=0.92, 95% CI: 0.71, 1.18). Thus risk for different cancers in distinct ethnic groups could be modulated by interaction between genetic variants and different endogenous and exogenous carcinogens."xsd:string |
| http://purl.uniprot.org/citations/18854828 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.bjc.6604683"xsd:string |
| http://purl.uniprot.org/citations/18854828 | http://purl.uniprot.org/core/author | "Kannan S."xsd:string |
| http://purl.uniprot.org/citations/18854828 | http://purl.uniprot.org/core/author | "Sarin R."xsd:string |
| http://purl.uniprot.org/citations/18854828 | http://purl.uniprot.org/core/author | "Mulherkar R."xsd:string |
| http://purl.uniprot.org/citations/18854828 | http://purl.uniprot.org/core/author | "Kotnis A."xsd:string |
| http://purl.uniprot.org/citations/18854828 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18854828 | http://purl.uniprot.org/core/name | "Br J Cancer"xsd:string |
| http://purl.uniprot.org/citations/18854828 | http://purl.uniprot.org/core/pages | "1340-1347"xsd:string |
| http://purl.uniprot.org/citations/18854828 | http://purl.uniprot.org/core/title | "Case-control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk."xsd:string |
| http://purl.uniprot.org/citations/18854828 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/18854828 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18854828 |
| http://purl.uniprot.org/citations/18854828 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18854828 |
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| http://purl.uniprot.org/uniprot/#_Q59GG0-mappedCitation-18854828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18854828 |
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| http://purl.uniprot.org/uniprot/P50225 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18854828 |
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| http://purl.uniprot.org/uniprot/Q59GG0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18854828 |