| http://purl.uniprot.org/citations/18922795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18922795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18922795 | http://www.w3.org/2000/01/rdf-schema#comment | "Huntingtin has been reported to regulate the nuclear translocation of the transcriptional repressor RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF). The REST/NRSF-interacting LIM domain protein (RILP) has also been shown to regulate REST/NRSF nuclear translocation. Therefore, we were prompted to address the question of how two distinct proteins could have the same function. We initially used a yeast two-hybrid screen to look for an interaction between huntingtin and RILP. This screen identified dynactin p150(Glued) as an interacting protein. Coimmunoprecipitation of proteins in vitro expressed in a reticulocyte lysate system showed an interaction between REST/NRSF and RILP as well as between RILP and dynactin p150(Glued). Coimmunoprecipitation analysis further showed a complex containing RILP, dynactin p150(Glued), and huntingtin. Huntingtin did not interact directly with either REST/NRSF or RILP, but did interact with dynactin p150(Glued). The N-terminal fragment of wild-type huntingtin did not affect the interaction between dynactin p150(Glued) and RILP; however, mutant huntingtin weakened this interaction. We further show that HAP1 (huntingtin-associated protein-1) prevents this complex from translocating REST/NRSF to the nucleus. Thus, this study suggests that REST/NRSF, dynactin p150(Glued), huntingtin, HAP1, and RILP form a complex involved in the translocation of REST/NRSF into the nucleus and that HAP1 controls REST/NRSF cellular localization in neurons."xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m804183200"xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m804183200"xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/author | "Shimojo M."xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/author | "Shimojo M."xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/pages | "34880-34886"xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/pages | "34880-34886"xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/title | "Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued."xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/title | "Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued."xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18922795 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18922795 |
| http://purl.uniprot.org/citations/18922795 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18922795 |
| http://purl.uniprot.org/citations/18922795 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18922795 |
| http://purl.uniprot.org/citations/18922795 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18922795 |
| http://purl.uniprot.org/uniprot/P54257 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18922795 |
| http://purl.uniprot.org/uniprot/P42858#attribution-2C9BB580BEAC6FAEF501B74740AE76FA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18922795 |
| http://purl.uniprot.org/uniprot/P42858#attribution-C7B22590AAE346DBE49AF5D9AB1FD325 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18922795 |
| http://purl.uniprot.org/uniprot/P54257#attribution-162505305677192339C0AE1C57E048A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18922795 |