| http://purl.uniprot.org/citations/18923542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18923542 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein-protein interaction plays a key role in the regulation of biological processes. The human potassium (HERG) channel is encoded by the ether-à-go-go-related gene (herg), and its activity may be regulated by association with other cellular proteins. To identify cellular proteins that might play a role in the regulation of the HERG channel, we screened a human heart cDNA library with the N terminus of HERG using a yeast 2-hybrid system, and identified caveolin-1 as a potential HERG partner. The interaction between these 2 proteins was confirmed by coimmunoprecipitation assay, and their overlapping subcellular localization was demonstrated by fluorescence immunocytochemistry. The physiologic implication of the protein-protein interaction was studied in whole-cell patch-clamp electrophysiology experiments. A significant increase in HERG current amplitude and a faster deactivation of tail current were observed in HEK293/HERG cells in a membrane lipid rafts disruption model and caveolin-1 knocked down cells by RNA interference. Alternatively, when caveolin-1 was overexpressed, the HERG current amplitude was significantly reduced and the tail current was deactivated more slowly. Taken together, these data indicate that HERG channels interact with caveolin-1 and are negatively regulated by this interaction. The finding from this study clearly demonstrates the regulatory role of caveolin-1 on HERG channels, and may help to understand biochemical events leading to arrhythmogenesis in the long QT syndrome in cardiac patients."xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.org/dc/terms/identifier | "doi:10.1139/o08-118"xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/author | "Lin S."xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/author | "Deng C."xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/author | "Choy P.C."xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/author | "Kuang S."xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/name | "Biochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/pages | "405-415"xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/title | "The regulation of the cardiac potassium channel (HERG) by caveolin-1."xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/18923542 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18923542 |
| http://purl.uniprot.org/citations/18923542 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18923542 |
| http://purl.uniprot.org/uniprot/Q03135#attribution-0D6A179917AA56CC65D43D33A7319664 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18923542 |
| http://purl.uniprot.org/uniprot/Q03135#attribution-5E642E6B7D387A033E4829CF83B01632 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18923542 |
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| http://purl.uniprot.org/uniprot/P41350#attribution-5E642E6B7D387A033E4829CF83B01632 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18923542 |
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