| http://purl.uniprot.org/citations/18925584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18925584 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesTo determine if low maternal serum level of pregnancy associated plasma protein A (PAPP-A) measured in early pregnancy can predict adverse pregnancy outcomes and to examine the gestational age (GA) sampling interval for these outcomes.MethodsThis was a nested case-control study from a prospective cohort of women recruited at <20 weeks of gestation in Halifax, NS. Cases (n=248) were defined as women who had a fetal loss or developed preeclampsia, severe pregnancy-induced hypertension (PIH), or small for gestational age infant (SGA). Controls (n=244) were frequency matched to cases by GA at the time of serum sampling (6 to <20 weeks GA). Participant information was obtained from questionnaires and medical chart reviews.ResultsWomen with a low PAPP-A measure [0.4 MoM). However, performance as a screening test was poor [sensitivity=38.7%; specificity=81.6%; positive likelihood ratio (LR)=2.1; negative LR=0.75]. In the adjusted model, the 10-to 14-week GA period was the only time period where low PAPP-A was significantly associated with adverse outcomes.ConclusionsWomen with a low PAPP-A early in their pregnancy have twice the risk of an adverse outcome, though PAPP-A as a one-time single marker test has limited value."xsd:string |
| http://purl.uniprot.org/citations/18925584 | http://purl.org/dc/terms/identifier | "doi:10.1002/pd.2116"xsd:string |
| http://purl.uniprot.org/citations/18925584 | http://purl.uniprot.org/core/author | "Dooley K."xsd:string |
| http://purl.uniprot.org/citations/18925584 | http://purl.uniprot.org/core/author | "Spencer C.A."xsd:string |
| http://purl.uniprot.org/citations/18925584 | http://purl.uniprot.org/core/author | "Allen V.M."xsd:string |
| http://purl.uniprot.org/citations/18925584 | http://purl.uniprot.org/core/author | "Dodds L."xsd:string |
| http://purl.uniprot.org/citations/18925584 | http://purl.uniprot.org/core/author | "Flowerdew G."xsd:string |
| http://purl.uniprot.org/citations/18925584 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18925584 | http://purl.uniprot.org/core/name | "Prenat Diagn"xsd:string |
| http://purl.uniprot.org/citations/18925584 | http://purl.uniprot.org/core/pages | "1029-1036"xsd:string |
| http://purl.uniprot.org/citations/18925584 | http://purl.uniprot.org/core/title | "Low levels of maternal serum PAPP-A in early pregnancy and the risk of adverse outcomes."xsd:string |
| http://purl.uniprot.org/citations/18925584 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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