| http://purl.uniprot.org/citations/18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18925687 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveWe previously showed that Adamantiades-Behçet's disease (A-BD) is associated with a lower incidence of malignancy compared with the general population. Transforming growth factor-beta (TGF-beta) has been shown to play a role in cartilage regeneration and is increased in patients with A-BD. We also found 2 functional polymorphisms of the TGF-beta pathway, TGFBR1*6A and TGFB1*CC, that are associated with risk of malignancy. We tested whether incidence of these polymorphisms would differ in patients with A-BD compared with healthy controls of similar age and geographic location.MethodsWe performed a case-control study including 139 cases and 128 controls from Greece. Cases and controls were genotyped for TGFBR1*6A and TGFB1*CC.ResultsWe found that cases had lower incidence of TGFBR1*6A compared with controls (11.3% vs 13.3%, respectively). Also, the incidence of TGFB1*CC was lower in cases than controls (24.6% vs 27.0%, respectively). These differences were not statistically significant.ConclusionAlthough there is a suggestion that the lower incidence of TGFBR1*6A in A-BD patients may play a protective role against development of malignancy, larger studies would be needed to fully evaluate the role of TGF-beta and its polymorphisms in A-BD."xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://purl.org/dc/terms/identifier | "doi:10.3899/jrheum.080676"xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://purl.uniprot.org/core/author | "Pasche B."xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://purl.uniprot.org/core/author | "Kaklamani V.G."xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://purl.uniprot.org/core/author | "Koumantaki Y."xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://purl.uniprot.org/core/author | "Sadim M."xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://purl.uniprot.org/core/author | "Kaklamanis P."xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18925687 | http://purl.uniprot.org/core/name | "J Rheumatol"xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://purl.uniprot.org/core/pages | "2376-2378"xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://purl.uniprot.org/core/title | "Role of polymorphisms in Adamantiades-Behcet's disease."xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/18925687 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18925687 |
| http://purl.uniprot.org/citations/18925687 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18925687 |
| http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18925687 |
| http://purl.uniprot.org/uniprot/#_A0A078BC11-mappedCitation-18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18925687 |
| http://purl.uniprot.org/uniprot/#_A0A078BCJ0-mappedCitation-18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18925687 |
| http://purl.uniprot.org/uniprot/#_A0A078BFK3-mappedCitation-18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18925687 |
| http://purl.uniprot.org/uniprot/#_A0A078BCH8-mappedCitation-18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18925687 |
| http://purl.uniprot.org/uniprot/#_A0A510GAF6-mappedCitation-18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18925687 |
| http://purl.uniprot.org/uniprot/#_A6MIV6-mappedCitation-18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18925687 |
| http://purl.uniprot.org/uniprot/#_A6MIV7-mappedCitation-18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18925687 |
| http://purl.uniprot.org/uniprot/#_A0A499FJK2-mappedCitation-18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18925687 |
| http://purl.uniprot.org/uniprot/#_B2C8Z3-mappedCitation-18925687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18925687 |