| http://purl.uniprot.org/citations/18927627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18927627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18927627 | http://www.w3.org/2000/01/rdf-schema#comment | "The Caenorhabditis elegans pharynx (or foregut) functions as a pump that draws in food (bacteria) from the environment. While the "organ identity factor" PHA-4 is critical for formation of the C. elegans pharynx as a whole, little is known about the specification of distinct cell types within the pharynx. Here, we use a combination of bioinformatics, molecular biology, and genetics to identify a helix-loop-helix transcription factor (HLH-6) as a critical regulator of pharyngeal gland development. HLH-6 is required for expression of a number of gland-specific genes, acting through a discrete cis-regulatory element named PGM1 (Pharyngeal Gland Motif 1). hlh-6 mutants exhibit a frequent loss of a subset of glands, while the remaining glands have impaired activity, indicating a role for hlh-6 in both gland development and function. Interestingly, hlh-6 mutants are also feeding defective, ascribing a biological function for the glands. Pharyngeal pumping in hlh-6 mutants is normal, but hlh-6 mutants lack expression of a class of mucin-related proteins that are normally secreted by pharyngeal glands and line the pharyngeal cuticle. An interesting possibility is that one function of pharyngeal glands is to secrete a pharyngeal lining that ensures efficient transport of food along the pharyngeal lumen."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000222"xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000222"xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/author | "Schnabel R."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/author | "Schnabel R."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/author | "Gaudet J."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/author | "Gaudet J."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/author | "Smit R.B."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/author | "Smit R.B."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/pages | "E1000222"xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/pages | "E1000222"xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/title | "The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/title | "The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function."xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/18927627 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18927627 |
| http://purl.uniprot.org/citations/18927627 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18927627 |
| http://purl.uniprot.org/citations/18927627 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18927627 |
| http://purl.uniprot.org/citations/18927627 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18927627 |