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http://purl.uniprot.org/citations/18928898http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18928898http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the expression of bone resorption regulators (receptor activator of nuclear factor kappa B [RANK], RANK ligand [RANKL], and osteoprotegerin [OPG]) in calcifying cystic odontogenic tumor (CCOT), adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), odontogenic myxoma (OM), and ameloblastic fibroma (AF).

Study design

The expression of these mediators was evaluated by means of immunohistochemistry.

Results

All specimens demonstrated positive immunoreactivity to RANK, RANKL, and OPG. The quantification of these mediators in epithelium revealed a similar pattern of expression for RANKL and OPG in CCOT, AOT, CEOT, and AF. With regard to stromal/mesenchymal cells, the majority of AOT and CCOT cases showed a higher content of OPG than RANKL, whereas CEOT, OM, and especially AF had a tendency to present a greater content of RANKL than OPG.

Conclusion

Our data indicate that the CCOT, AOT, CEOT, OM, and AF cell constituents express key regulators of bone metabolism that might locally modulate tumor-associated bone resorption."xsd:string
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http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/author"Sousa D.P."xsd:string
http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/author"Batista A.C."xsd:string
http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/author"Mendonca E.F."xsd:string
http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/author"Silva T.A."xsd:string
http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/author"Lara V.S."xsd:string
http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/author"Andrade F.R."xsd:string
http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/name"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"xsd:string
http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/pages"548-555"xsd:string
http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/title"Expression of bone resorption regulators (RANK, RANKL, and OPG) in odontogenic tumors."xsd:string
http://purl.uniprot.org/citations/18928898http://purl.uniprot.org/core/volume"106"xsd:string
http://purl.uniprot.org/citations/18928898http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18928898
http://purl.uniprot.org/citations/18928898http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18928898
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http://purl.uniprot.org/uniprot/O14788http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18928898
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