| http://purl.uniprot.org/citations/18930133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18930133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18930133 | http://www.w3.org/2000/01/rdf-schema#comment | "IKKbeta serves as a central intermediate signaling molecule in the activation of the NF-kappaB pathway. However, the precise mechanism for the termination of IKKbeta activity is still not fully understood. Using a functional genomic approach, we have identified two protein serine/threonine phosphatases, PPM1A and PPM1B, as IKKbeta phosphatases. Overexpression of PPM1A or PPM1B results in dephosphorylation of IKKbeta at Ser177 and Ser181 and termination of IKKbeta-induced NF-kappaB activation. PPM1A and PPM1B associate with the phosphorylated form of IKKbeta, and the interaction between PPM1A/PPM1B and IKKbeta is induced by TNFalpha in a transient fashion in the cells. Furthermore, knockdown of PPM1A and PPM1B expression enhances TNFalpha-induced IKKbeta phosphorylation, NF-kappaB nuclear translocation and NF-kappaB-dependent gene expression. These data suggest that PPM1A and PPM1B play an important role in the termination of TNFalpha-mediated NF-kappaB activation through dephosphorylating and inactivating IKKbeta."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2008.09.012"xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2008.09.012"xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Chu M."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Chu M."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Fu S."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Fu S."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Tan X."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Tan X."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Shen T."xsd:string |
| http://purl.uniprot.org/citations/18930133 | http://purl.uniprot.org/core/author | "Shen T."xsd:string |