| http://purl.uniprot.org/citations/18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18936092 | http://www.w3.org/2000/01/rdf-schema#comment | "gamma-Synuclein (Syn G) is highly expressed in retinal ganglion cells and the loss of these cells in glaucoma is associated with significant reduction of the intracellular Syn G level. However, a causative relationship between these two events has not been established. Here we show that the knockdown of Syn G results in a decreased viability of the immortalized retinal ganglion cells (RGC-5). The Syn G silencing reduces phosphorylation of serine 112 (Ser112) in Bad protein, a member of the Bcl-2 family that plays a critical role in apoptotic cell death signaling. Our gene expression analysis data suggests that changes in Bad phosphorylation status may be caused by a coordinated shift in activities of kinases controlling Bad phosphorylation and phosphatases catalyzing its dephosphorylation. Moreover, increased phosphorylation of Bad-sequestering protein 14-3-3 detected in these cells is also pro-apoptotic. These results suggest that the homeostatic level of Syn G in RGC-5 cells is required for transcriptional regulation of protein kinases and phosphatases, controlling phosphorylation of Bad and 14-3-3. Lowering Syn G causes Bad dephosphorylation, dissociation from phosphorylated 14-3-3, and translocation to mitochondria where it initiates apoptotic death cascade."xsd:string |
| http://purl.uniprot.org/citations/18936092 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m806660200"xsd:string |
| http://purl.uniprot.org/citations/18936092 | http://purl.uniprot.org/core/author | "Shestopalov V.I."xsd:string |
| http://purl.uniprot.org/citations/18936092 | http://purl.uniprot.org/core/author | "Surguchov A."xsd:string |
| http://purl.uniprot.org/citations/18936092 | http://purl.uniprot.org/core/author | "Surgucheva I."xsd:string |
| http://purl.uniprot.org/citations/18936092 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18936092 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18936092 | http://purl.uniprot.org/core/pages | "36377-36385"xsd:string |
| http://purl.uniprot.org/citations/18936092 | http://purl.uniprot.org/core/title | "Effect of gamma-synuclein silencing on apoptotic pathways in retinal ganglion cells."xsd:string |
| http://purl.uniprot.org/citations/18936092 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18936092 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18936092 |
| http://purl.uniprot.org/citations/18936092 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18936092 |
| http://purl.uniprot.org/uniprot/Q63544#attribution-E014130B8C9B5791B21625F0FD14F838 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K0T6-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_A6HGT3-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_A6HGT4-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_A6HGT5-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_A6HGT6-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_A6HGT7-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_A6KFR9-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_A6KFS0-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_A6KFS1-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_A6KFS2-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |
| http://purl.uniprot.org/uniprot/#_F1LQ96-mappedCitation-18936092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936092 |