| http://purl.uniprot.org/citations/18936204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18936204 | http://www.w3.org/2000/01/rdf-schema#comment | "One mechanism through which bioactive food components may exert anticancer effects is by reducing the expression of the proinflammatory gene cyclooxygenase-2 (COX-2), which has been regarded as a risk factor in tumor development. Rosmarinic acid (RA) is a phenolic derivative of caffeic acid present in rosemary (Rosmarinus officinalis). Previous research documented that RA may exert antiinflammatory effects. However, the mechanisms of action of RA on COX-2 expression have not been investigated. Here, we report that in colon cancer HT-29 cells, RA (5, 10, and 20 micromol/L) reduced the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter activity (P < 0.05) and protein levels (P < 0.05). In addition, the cotreatment with RA reduced (5 micromol/L, P < 0.05; 10 and 20 micromol/L, P < 0.01) TPA-induced transcription from a control activator protein-1 (AP-1) promoter-luciferase construct and repressed binding of the AP-1 factors c-Jun (10 micromol/L; P < 0.01) and c-Fos (10 micromol/L; P < 0.05) to COX-2 promoter oligonucleotides harboring a cAMP-response element (CRE). The anti-AP1 effects of RA were also examined in a nonmalignant breast epithelial cell line (MCF10A) in which RA antagonized the stimulatory effects of TPA on COX-2 protein expression (5 micromol/L, P < 0.05; 10 and 20 micromol/L, P < 0.01), the recruitment of c-Jun and c-Fos (10 micromol/L; P < 0.01) to the COX-2/CRE oligonucleotides, and activation of the extracellular signal-regulated protein kinase-1/2 (ERK1/2) (10 micromol/L; P < 0.01), a member of the mitogen-activated protein kinase pathway. Additionally, RA antagonized ERK1/2 activation in colon HT-29 and breast MCF-7 cancer cells (10 micromol/L; P < 0.01). Thus, we propose that RA may be an effective preventative agent against COX-2 activation by AP-1-inducing agents in both cancer and nonmalignant mammary epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/18936204 | http://purl.org/dc/terms/identifier | "doi:10.3945/jn.108.090431"xsd:string |
| http://purl.uniprot.org/citations/18936204 | http://purl.uniprot.org/core/author | "Romagnolo D.F."xsd:string |
| http://purl.uniprot.org/citations/18936204 | http://purl.uniprot.org/core/author | "Degner S.C."xsd:string |
| http://purl.uniprot.org/citations/18936204 | http://purl.uniprot.org/core/author | "Scheckel K.A."xsd:string |
| http://purl.uniprot.org/citations/18936204 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18936204 | http://purl.uniprot.org/core/name | "J Nutr"xsd:string |
| http://purl.uniprot.org/citations/18936204 | http://purl.uniprot.org/core/pages | "2098-2105"xsd:string |
| http://purl.uniprot.org/citations/18936204 | http://purl.uniprot.org/core/title | "Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines."xsd:string |
| http://purl.uniprot.org/citations/18936204 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/18936204 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18936204 |
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| http://purl.uniprot.org/uniprot/#_A0A510GAI3-mappedCitation-18936204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936204 |
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| http://purl.uniprot.org/uniprot/#_Q8IZA9-mappedCitation-18936204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936204 |
| http://purl.uniprot.org/uniprot/#_Q6FHK0-mappedCitation-18936204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936204 |
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| http://purl.uniprot.org/uniprot/P35354 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18936204 |