| http://purl.uniprot.org/citations/18936542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18936542 | http://www.w3.org/2000/01/rdf-schema#comment | "Background/aimHLA-A is a locus of the major histocompatibility complex situated on chromosome 6p21.3. Several genome-wide linkage analyses suggested that a putative locus predisposition for Alzheimer's disease (AD) is found on chromosome 6p21. In this study, we investigated the association between HLA-A alleles and AD in a Chinese community.MethodsFine genotyping of 160 Chinese AD and 167 age-matched nondemented subjects was performed for the first time by sequence-based typing of the HLA-A locus.ResultsWe found that HLA-A2 carriers (including prevalent alleles, 0201, 0203 and 0207) were more prevalent in the AD group; the frequency of HLA-A2 was increased in AD patients versus controls, but the difference was not significant after Bonferroni correction for the number of alleles tested (p = 0.075). A gene-gene interaction was observed between ApoE and HLA-A, the presence of HLA-A24 (particularly the prevalent allele 2402) might act as another independent risk factor of developing AD for subjects not carrying the ApoE epsilon4 allele (relative risk = 2.98, 95% CI = 1.14-8.24). Carriers of HLA-A2 had an earlier onset of AD by 2.4 years (p = 0.030) and HLA-A2 interacted with ApoE epsilon4 in modulating the age at onset in AD.ConclusionsThis study suggested that HLA-A may be involved in the pathogenesis of AD."xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.org/dc/terms/identifier | "doi:10.1159/000164275"xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/author | "Tang N.L."xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/author | "Chiu H.F."xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/author | "Lam L.C."xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/author | "Ma S.L."xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/author | "Suen E.W."xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/author | "Lui V.W."xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/author | "Tam C.W."xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/name | "Dement Geriatr Cogn Disord"xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/pages | "391-397"xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/title | "Association between HLA-A alleles and Alzheimer's disease in a southern Chinese community."xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/18936542 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18936542 |
| http://purl.uniprot.org/citations/18936542 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18936542 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-18936542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936542 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-18936542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936542 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-18936542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936542 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-18936542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936542 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N5-mappedCitation-18936542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936542 |
| http://purl.uniprot.org/uniprot/#_A0A076JXB7-mappedCitation-18936542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936542 |
| http://purl.uniprot.org/uniprot/#_A0A076L0P9-mappedCitation-18936542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18936542 |
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