| http://purl.uniprot.org/citations/18941116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18941116 | http://www.w3.org/2000/01/rdf-schema#comment | "Urokinase-type plasminogen activator (uPA) signaling via its receptor uPAR inhibits late events in HIV-1 replication in acutely infected primary monocyte-derived macrophages (MDMs) and promonocytic U937 cells. Here we show that U937-derived, chronically infected U1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) express integrins, uPA, and soluble uPAR at levels similar to those of MDMs. uPA inhibited HIV expression in U1 cells incubated with either PMA or tumor necrosis factor-alpha (TNF-alpha), but not with other HIV-inductive cytokines or lipopolysaccharide. Of interest, only PMA and TNF-alpha, but not other HIV-inductive stimuli, induced surface expression of the alpha(M) chain CD11b in U1 cells constitutively expressing CD18, the beta(2) chain of the Mac-1 integrin. Like uPA, fibrinogen, a Mac-1 (CD11b/CD18) ligand, and M25, a peptide homologous to a portion of the beta-propeller region of CD11b preventing its association with uPAR, inhibited HIV virion release in PMA-stimulated U1 cells. Both uPAR small-interference RNA (siRNA) and soluble anti-beta(1)/-beta(2) monoclonal antibodies abolished the anti-HIV effects of uPA, whereas CD11b siRNA reversed the anti-HIV effect of M25, but not that induced by uPA. Thus, either uPA/uPAR interaction, Mac-1 activation, or prevention of its association with uPAR triggers a signaling pathway leading to the inefficient release of HIV from monocytic cells."xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-02-138412"xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/author | "Poli G."xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/author | "Blasi F."xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/author | "Alfano M."xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/author | "Pardi R."xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/author | "Mariani S.A."xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/author | "Elia C."xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/pages | "1699-1709"xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/title | "Ligand-engaged urokinase-type plasminogen activator receptor and activation of the CD11b/CD18 integrin inhibit late events of HIV expression in monocytic cells."xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/18941116 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18941116 |
| http://purl.uniprot.org/citations/18941116 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18941116 |
| http://purl.uniprot.org/uniprot/#_A0A024D9P8-mappedCitation-18941116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941116 |
| http://purl.uniprot.org/uniprot/#_A0A024D9S0-mappedCitation-18941116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941116 |
| http://purl.uniprot.org/uniprot/#_A0A024DAE5-mappedCitation-18941116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941116 |
| http://purl.uniprot.org/uniprot/#_A0A024DAF4-mappedCitation-18941116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941116 |
| http://purl.uniprot.org/uniprot/#_A0A024DAS2-mappedCitation-18941116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941116 |
| http://purl.uniprot.org/uniprot/#_A0A024DAS5-mappedCitation-18941116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941116 |
| http://purl.uniprot.org/uniprot/#_A0A024DAT2-mappedCitation-18941116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941116 |
| http://purl.uniprot.org/uniprot/#_A0A024DBF0-mappedCitation-18941116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941116 |
| http://purl.uniprot.org/uniprot/#_A0A024DBF8-mappedCitation-18941116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941116 |