| http://purl.uniprot.org/citations/18941117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18941117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18941117 | http://www.w3.org/2000/01/rdf-schema#comment | "Precise transcriptional control of developmental stage-specific expression and switching of alpha- and beta-globin genes is significantly important to understand the general principles controlling gene expression and the pathogenesis of thalassemia. Although transcription factors regulating beta-globin genes have been identified, little is known about the microRNAs and trans-acting mechanism controlling alpha-globin genes transcription. Here, we show that an erythroid lineage-specific microRNA gene, miR-144, expressed at specific developmental stages during zebrafish embryogenesis, negatively regulates the embryonic alpha-globin, but not embryonic beta-globin, gene expression, through physiologically targeting klfd, an erythroid-specific Krüppel-like transcription factor. Klfd selectively binds to the CACCC boxes in the promoters of both alpha-globin and miR-144 genes to activate their transcriptions, thus forming a negative feedback circuitry to fine-tune the expression of embryonic alpha-globin gene. The selective effect of the miR-144-Klfd pathway on globin gene regulation may thereby constitute a novel therapeutic target for improving the clinical outcome of patients with thalassemia."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-08-174854"xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-08-174854"xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Deng M."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Deng M."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Dong M."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Dong M."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Fu Y.F."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Fu Y.F."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Liu T.X."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Liu T.X."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Zhu K.Y."xsd:string |
| http://purl.uniprot.org/citations/18941117 | http://purl.uniprot.org/core/author | "Zhu K.Y."xsd:string |