| http://purl.uniprot.org/citations/18941246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18941246 | http://www.w3.org/2000/01/rdf-schema#comment | "Lung-specific thymic stromal lymphopoietin (TSLP) expression is sufficient for the development of an asthma-like chronic airway inflammatory disease. However, the nature of the downstream pathways that regulate disease development are not known. In this study, we used IL-4- and Stat6-deficient mice to establish the role of Th2-type responses downstream of TSLP. IL-4 deficiency greatly reduced, but did not eliminate, TSLP-induced airway hyperresponsiveness, airway inflammation, eosinophilia, and goblet cell metaplasia, while Stat6 deficiency eliminated these asthma-like symptoms. We further demonstrate, using the chronic model of TSLP-mediated airway inflammation, that blockade of both IL-4 and IL-13 responses, through administration of an anti-IL-4R alpha mAb, reversed asthma-like symptoms, when given to mice with established disease. Collectively these data provide insight into the pathways engaged in TSLP-driven airway inflammation and demonstrate that simultaneous blockade of IL-4 and IL-13 can reverse established airway disease, suggesting that this may be an effective approach for the therapy of Th2-mediated inflammatory respiratory disease."xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.181.9.6557"xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/author | "Zhou B."xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/author | "Comeau M.R."xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/author | "Ziegler S.F."xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/author | "Tocker J."xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/author | "Aye T."xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/author | "Headley M.B."xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/pages | "6557-6562"xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/title | "Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses."xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/18941246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18941246 |
| http://purl.uniprot.org/citations/18941246 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18941246 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG43-mappedCitation-18941246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941246 |
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| http://purl.uniprot.org/uniprot/#_G8Z3H3-mappedCitation-18941246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18941246 |
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