| http://purl.uniprot.org/citations/18942717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18942717 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix Metalloproteinase-9 (MMP-9) consists of a prodomain, catalytic domain with 3 fibronectin-like type II modules and C-terminal hemopexin-like (PEX) domain. These domains play distinct roles in terms of proteolytic activity, substrate binding and interaction with inhibitors and receptors. To assess the potential of the MMP-9-PEX domain to interfere with tumor progression, we stably transfected human glioblastoma cells with an expression vector containing a cDNA sequence of the MMP-9-PEX. The selected clones exhibited decreased MMP-9 activity and reduced invasive capacity. We assessed how secretion of MMP-9-PEX by glioblastoma cells affects angiogenic capabilities of human microvascular endothelial cells (HMECs) in vitro. MMP-9-PEX conditioned medium treatment caused a reduction in migration of HMECs and inhibited capillary-like structure formation in association with suppression of vascular endothelial growth factor (VEGF) secretion and VEGF receptor-2 protein level. The suppression of HMECs survival by conditioned medium from MMP-9-PEX stable transfectants was associated with apoptosis induction characterized by an increase in cells with a sub-G0/G1 content, fragmentation of DNA, caspase-3, -8 and -9 activation and poly (ADP-ribose) polymerase (PARP) cleavage. A significant tumor growth inhibition was observed in intracranial implants of MMP-9-PEX stable transfectants in nude mice with attenuation of CD31 and MMP-9 protein expression. These results demonstrate that MMP-9-PEX inhibits angiogenic features of endothelial cells and retards intracranial glioblastoma growth."xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.23951"xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/author | "Gujrati M."xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/author | "Rao J.S."xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/author | "Jadhav U."xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/author | "Mohanam S."xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/author | "Ezhilarasan R."xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/author | "Mohanam I."xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/pages | "306-315"xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/title | "The hemopexin domain of MMP-9 inhibits angiogenesis and retards the growth of intracranial glioblastoma xenograft in nude mice."xsd:string |
| http://purl.uniprot.org/citations/18942717 | http://purl.uniprot.org/core/volume | "124"xsd:string |
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