| http://purl.uniprot.org/citations/18945962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18945962 | http://www.w3.org/2000/01/rdf-schema#comment | "Survival for patients with acute myeloid leukemia (AML) is limited by treatment-related mortality (TRM) and relapse after unrelated donor (URD) hematopoietic cell transplantation (HCT). Natural killer (NK)-cell alloreactivity, determined by donor killer-cell immunoglobulin-like receptors (KIRs) and recipient HLA, correlates with successful HCT for AML. Hypothesizing that donor KIR genotype (A/A: 2 A KIR haplotypes; B/x: at least 1 B haplotype) would affect outcomes, we genotyped donors and recipients from 209 HLA-matched and 239 mismatched T-replete URD transplantations for AML. Three-year overall survival was significantly higher after transplantation from a KIR B/x donor (31% [95% CI: 26-36] vs 20% [95% CI: 13-27]; P = .007). Multivariate analysis demonstrated a 30% improvement in the relative risk of relapse-free survival with B/x donors compared with A/A donors (RR: 0.70 [95% CI: 0.55-0.88]; P = .002). B/x donors were associated with a higher incidence of chronic graft-versus-host disease (GVHD; RR: 1.51 [95% CI: 1.01-2.18]; P = .03), but not of acute GVHD, relapse, or TRM. This analysis demonstrates that unrelated donors with KIR B haplotypes confer significant survival benefit to patients undergoing T-replete HCT for AML. KIR genotyping of prospective donors, in addition to HLA typing, should be performed to identify HLA-matched donors with B KIR haplotypes."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-07-171926"xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Klein J."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Parham P."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Miller J.S."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Marsh S.G."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Trachtenberg E."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Guethlein L.A."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Cooley S."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Le C.T."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Weisdorf D.J."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Bergemann T.L."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/author | "Saeteurn K."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/pages | "726-732"xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/title | "Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia."xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/18945962 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18945962 |
| http://purl.uniprot.org/citations/18945962 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18945962 |
| http://purl.uniprot.org/uniprot/#_A0A0C4ZLQ8-mappedCitation-18945962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18945962 |
| http://purl.uniprot.org/uniprot/#_A0A0C4ZN05-mappedCitation-18945962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18945962 |
| http://purl.uniprot.org/uniprot/#_A0A0C4ZN08-mappedCitation-18945962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18945962 |
| http://purl.uniprot.org/uniprot/#_A0A0C4ZN11-mappedCitation-18945962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18945962 |