| http://purl.uniprot.org/citations/18946501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18946501 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundMany membrane proteins, including Drosophila Dscam, are enriched in dendrites or axons within neurons. However, little is known about how the differential distribution is established and maintained.Methodology/principal findingsHere we investigated the mechanisms underlying the dendritic targeting of Dscam[TM1]. Through forward genetic mosaic screens and by silencing specific genes via targeted RNAi, we found that several genes, encoding various components of the dynein-dynactin complex, are required for restricting Dscam[TM1] to the mushroom body dendrites. In contrast, compromising dynein/dynactin function did not affect dendritic targeting of two other dendritic markers, Nod and Rdl. Tracing newly synthesized Dscam[TM1] further revealed that compromising dynein/dynactin function did not affect the initial dendritic targeting of Dscam[TM1], but disrupted the maintenance of its restriction to dendrites.Conclusions/significanceThe results of this study suggest multiple mechanisms of dendritic protein targeting. Notably, dynein-dynactin plays a role in excluding dendritic Dscam, but not Rdl, from axons by retrograde transport."xsd:string |
| http://purl.uniprot.org/citations/18946501 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0003504"xsd:string |
| http://purl.uniprot.org/citations/18946501 | http://purl.uniprot.org/core/author | "Lee T."xsd:string |
| http://purl.uniprot.org/citations/18946501 | http://purl.uniprot.org/core/author | "Yang J.S."xsd:string |
| http://purl.uniprot.org/citations/18946501 | http://purl.uniprot.org/core/author | "Bai J.M."xsd:string |
| http://purl.uniprot.org/citations/18946501 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18946501 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/18946501 | http://purl.uniprot.org/core/pages | "e3504"xsd:string |
| http://purl.uniprot.org/citations/18946501 | http://purl.uniprot.org/core/title | "Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam."xsd:string |
| http://purl.uniprot.org/citations/18946501 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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