| http://purl.uniprot.org/citations/18947875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18947875 | http://www.w3.org/2000/01/rdf-schema#comment | "The rodent-specific complement regulator complement receptor 1-related gene/protein-y (Crry) is critical for complement homeostasis. Gene deletion is 100% embryonically lethal; Crry-deficient (Crry(-/-)) mice were rescued by back-crossing onto C3 deficiency, confirming that embryo loss was complement mediated. In order to rescue viable Crry(-/-) mice without deleting C3, we have tested inhibition of C5 during gestation. Crry(+/-) females were given neutralizing anti-C5 mAb immediately prior to mating with Crry(+/-) males and C5 inhibition maintained through pregnancy. A single, healthy Crry(-/-) female was obtained and mating with Crry(+/-) males yielded healthy litters containing equal numbers of Crry(+/-) and Crry(-/-) pups. Inter-crossing Crry(-/-) mice yielded healthy litters of expected size. Although the mice were not anemic, exposure of Crry(-/-) erythrocytes to normal mouse serum caused C3 deposition and lysis, while transfusion into normal or C6(-/-) mice resulted in rapid clearance. Complement activity and C3 levels in Crry(-/-) mice were markedly reduced. Comparison with factor H deficient (CfH(-/-)) mice revealed similar levels of residual C3; however, unlike the CfH(-/-) mice, Crry(-/-) mice showed no evidence of renal injury, demonstrating distinct roles for these regulators in protecting the kidney."xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2008.09.003"xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/author | "Harris C.L."xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/author | "Morgan B.P."xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/author | "Hughes T.R."xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/author | "Pickering M.C."xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/author | "Sivasankar B."xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/author | "Donev R.M."xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/author | "Ruseva M.M."xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/pages | "803-811"xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/title | "Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury."xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/18947875 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18947875 |
| http://purl.uniprot.org/citations/18947875 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18947875 |
| http://purl.uniprot.org/uniprot/O55186#attribution-26DB32DA0E63674887C312EC832F6567 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18947875 |
| http://purl.uniprot.org/uniprot/P06684#attribution-ED094824B8D7FF8A539D46AFD7D2C893 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18947875 |
| http://purl.uniprot.org/uniprot/P01027#attribution-26DB32DA0E63674887C312EC832F6567 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18947875 |
| http://purl.uniprot.org/uniprot/Q64735#attribution-26DB32DA0E63674887C312EC832F6567 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18947875 |
| http://purl.uniprot.org/uniprot/Q64735#attribution-ED094824B8D7FF8A539D46AFD7D2C893 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18947875 |
| http://purl.uniprot.org/uniprot/Q64735#attribution-EFADDB24813A73DFAF59679F1CEB4A15 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18947875 |
| http://purl.uniprot.org/uniprot/P06909#attribution-EFADDB24813A73DFAF59679F1CEB4A15 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18947875 |