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http://purl.uniprot.org/citations/18948092http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18948092http://www.w3.org/2000/01/rdf-schema#comment"

Background

The Nogo isoforms A, B and C are members of the reticulon family of proteins. Nogo-B is found in most tissues, especially highly expressed in endothelial and smooth muscle cells of the vessel wall, and Nogo-B is a regulator of cell migration in vitro and vascular remodeling in vivo. The TATC and CAA 3'UTR insertion/deletion polymorphisms of the RTN4, the gene encoding Nogo isoforms A, B and C, have been linked to schizophrenia and depression, but data were inconsistent. However, it is unclear whether these polymorphisms are associated with dilated cardiomyopathy (DCM).

Methods

A total of 159 DCM patients and 215 control subjects were recruited in this study. The RTN4 TATC and CAA insertion/deletion genotypes were determined using PCR-polyacrylamide gel electrophoresis.

Results

Frequencies of (TATC)(2) allele and (TATC)(2)/(TATC)(2) genotype were significantly different from that in healthy controls (P = 0.045, OR = 1.356, 95% CI = 1.006-1.827 and P = 0.021, OR = 2.094, 95% CI = 1.113-3.940, respectively). No significant differences in CAA insertion/deletion genotype and allele frequencies were observed between the DCM and controls.

Conclusion

These data provide evidence that RTN4 allele (TATC)(2) and (TATC)(2)/(TATC)(2) genotype are associated with DCM."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.org/dc/terms/identifier"doi:10.1016/j.cca.2008.09.028"xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Chen Y."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Gao L."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Li C."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Song Y."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Xue H."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Zhang L."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Zhou B."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Peng Y."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Liang W."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Rao L."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/author"Lv M."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/name"Clin Chim Acta"xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/pages"21-24"xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/title"The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms."xsd:string
http://purl.uniprot.org/citations/18948092http://purl.uniprot.org/core/volume"400"xsd:string
http://purl.uniprot.org/citations/18948092http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18948092
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http://purl.uniprot.org/uniprot/#_A6XGP7-mappedCitation-18948092http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18948092
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