| http://purl.uniprot.org/citations/18948124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18948124 | http://www.w3.org/2000/01/rdf-schema#comment | "5-HT(7) receptors are involved in REM sleep and possibly in mood disorders. REM sleep suppression and antidepressant-like behavior is observed in 5-HT(7)(-/-) mice and in rats treated with 5-HT(7) receptor antagonists. We recently demonstrated that pharmacological blockade of 5-HT(7) receptors enhances REM sleep suppression and antidepressant-like behavior induced by citalopram in rodents. It has been hypothesized that the effect of citalopram on sleep is essentially mediated by the activation of 5-HT(1A) receptors. The present study investigates the impact of 5-HT(7) receptor gene deletion on the effect of various reuptake inhibitors on REM sleep and probes the role of 5-HT(1A) receptors in this response. Three SSRIs (citalopram, fluoxetine and paroxetine) but not the tricyclic antidepressant desipramine had a significantly stronger REM sleep suppressive effect in 5-HT(7)(-/-) mice compared to 5-HT(7)(+/+) mice. In contrast, REM sleep was similarly reduced in 5-HT(7)(+/+) mice and 5-HT(7)(-/-) mice after treatment with the 5-HT(1A) receptor agonist ipsapirone. Furthermore, both 5-HT(7)(+/+) and 5-HT(7)(-/-) mice displayed the same increase in REM sleep duration produced by the 5-HT(1A) receptor antagonist WAY-100635. These findings indicate that 5-HT(7) receptor deletion augments the effect of various SSRIs on REM sleep suppression and that this effect is distinct from those mediated via 5-HT(1A) receptors."xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuropharm.2008.09.014"xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/author | "Bonaventure P."xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/author | "Yun S."xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/author | "Shelton J."xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/author | "Lovenberg T."xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/author | "Dugovic C."xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/name | "Neuropharmacology"xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/pages | "448-454"xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/title | "5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor."xsd:string |
| http://purl.uniprot.org/citations/18948124 | http://purl.uniprot.org/core/volume | "56"xsd:string |
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