| http://purl.uniprot.org/citations/18948948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18948948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18948948 | http://www.w3.org/2000/01/rdf-schema#comment | "BAX is a pro-apoptotic protein of the BCL-2 family that is stationed in the cytosol until activated by a diversity of stress stimuli to induce cell death. Anti-apoptotic proteins such as BCL-2 counteract BAX-mediated cell death. Although an interaction site that confers survival functionality has been defined for anti-apoptotic proteins, an activation site has not been identified for BAX, rendering its explicit trigger mechanism unknown. We previously developed stabilized alpha-helix of BCL-2 domains (SAHBs) that directly initiate BAX-mediated mitochondrial apoptosis. Here we demonstrate by NMR analysis that BIM SAHB binds BAX at an interaction site that is distinct from the canonical binding groove characterized for anti-apoptotic proteins. The specificity of the human BIM-SAHB-BAX interaction is highlighted by point mutagenesis that disrupts functional activity, confirming that BAX activation is initiated at this novel structural location. Thus, we have now defined a BAX interaction site for direct activation, establishing a new target for therapeutic modulation of apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07396"xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07396"xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Cheng E.H."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Cheng E.H."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Tjandra N."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Tjandra N."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Bird G.H."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Bird G.H."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Davis M.L."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Davis M.L."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Gavathiotis E."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Gavathiotis E."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Katz S.G."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Katz S.G."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Pitter K."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Pitter K."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Tu H.C."xsd:string |
| http://purl.uniprot.org/citations/18948948 | http://purl.uniprot.org/core/author | "Tu H.C."xsd:string |