DESCRIBE <http://purl.uniprot.org/citations/18949044>

Subject	Predicate	Object
http://purl.uniprot.org/citations/18949044	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18949044	http://www.w3.org/2000/01/rdf-schema#comment	" Background Homologous chromosomes separate in meiosis I and sister chromatids separate in meiosis II, generating haploid gametes. To address the question why sister chromatids do not separate in meiosis I, we explored the roles of Shogoshin1 (Sgo1) in chromosome separation during oocyte meiosis. Methodology/principal findings Sgo1 function was evaluated by exogenous overexpression to enhance its roles and RNAi to suppress its roles during two meioses of mouse oocytes. Immunocytochemistry and chromosome spread were used to evaluate phenotypes. The exogenous Sgo1 overexpression kept homologous chromosomes and sister chromatids not to separate in meiosis I and meiosis II, respectively, while the Sgo1 RNAi promoted premature separation of sister chromatids. Conclusions Our results reveal that prevention of premature separation of sister chromatids in meiosis I requires the retention of centromeric Sgo1, while normal separation of sister chromatids in meiosis II requires loss of centromeric Sgo1."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.org/dc/terms/identifier	"doi:10.1371/journal.pone.0003516"xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/author	"Hou Y."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/author	"Wei L."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/author	"Yuan J."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/author	"Yin S."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/author	"Chen D.Y."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/author	"Schatten H."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/author	"Sun Q.Y."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/author	"Ouyang Y.C."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/author	"Shi L.H."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/author	"Ai J.S."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/date	"2008"xsd:gYear
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/name	"PLoS One"xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/pages	"e3516"xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/title	"Shugoshin1 may play important roles in separation of homologous chromosomes and sister chromatids during mouse oocyte meiosis."xsd:string
http://purl.uniprot.org/citations/18949044	http://purl.uniprot.org/core/volume	"3"xsd:string
http://purl.uniprot.org/citations/18949044	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/18949044
http://purl.uniprot.org/citations/18949044	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/18949044
http://purl.uniprot.org/uniprot/#_Q9CXH7-mappedCitation-18949044	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18949044
http://purl.uniprot.org/uniprot/Q9CXH7	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/18949044