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http://purl.uniprot.org/citations/18949272http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18949272http://www.w3.org/2000/01/rdf-schema#comment"

Objective

As axon outgrowth and dentate granule cell neurogenesis are hallmarks of hippocampal development and are also the two morphologic changes in the structure of the dentate gyrus after status epilepticus (SE), we hypothesized that molecules involved in normal development may also play a role during epileptogenesis.

Method

Using in situ hybridization, we have characterized mRNA expression of myocyte-specific enhancer binding factor 2C (MEF2C) in the dentate gyrus during development (P0, P3, P7, P14 and P28) and at multiple time points following pilocarpine-induced SE (3, 7, 14, 28 days after SE).

Results

It was demonstrated that MEF2C is up-regulated during development (P0, P3, P7, P14 and P28) and in the adult rat dentate gyrus following SE (3, 7, 14, 28 days after SE).

Conclusions

The molecules controlling cell-fate decisions in the developing dentate gyrus are also operative during epileptogenesis."xsd:string
http://purl.uniprot.org/citations/18949272http://purl.org/dc/terms/identifier"doi:10.1590/s0004-282x2008000500024"xsd:string
http://purl.uniprot.org/citations/18949272http://purl.uniprot.org/core/author"Cavalheiro E.A."xsd:string
http://purl.uniprot.org/citations/18949272http://purl.uniprot.org/core/author"Scorza F.A."xsd:string
http://purl.uniprot.org/citations/18949272http://purl.uniprot.org/core/author"Scorza C.A."xsd:string
http://purl.uniprot.org/citations/18949272http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18949272http://purl.uniprot.org/core/name"Arq Neuropsiquiatr"xsd:string
http://purl.uniprot.org/citations/18949272http://purl.uniprot.org/core/pages"731-735"xsd:string
http://purl.uniprot.org/citations/18949272http://purl.uniprot.org/core/title"Myocyte-specific enhancer binding factor 2C (MEF2C) expression in the dentate gyrus during development and after pilocarpine-induced status epilepticus: a preliminary report."xsd:string
http://purl.uniprot.org/citations/18949272http://purl.uniprot.org/core/volume"66"xsd:string
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