| http://purl.uniprot.org/citations/18952430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18952430 | http://www.w3.org/2000/01/rdf-schema#comment | "As with many skeletal muscle diseases, the extraocular muscles (EOMs) are spared in skeletal muscle alpha-actin diseases, with no ophthalmoplegia even in severely affected patients. We hypothesised that the extraocular muscles sparing in these patients was due to significant expression of cardiac alpha-actin, the alpha-actin isoform expressed in heart and foetal skeletal muscle. We have shown by immunochemistry, Western blotting and a novel MRM-mass spectrometry technique, comparable levels of cardiac alpha-actin in the extraocular muscles of human, pig and sheep to those in the heart. The sparing of extraocular muscles in skeletal muscle alpha-actin disease is thus probably due to greater levels of cardiac alpha-actin, than the negligible amounts in skeletal muscles, diluting out the effects of the mutant skeletal muscle alpha-actin."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.nmd.2008.09.010"xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/author | "Bringans S."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/author | "Laing N.G."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/author | "Ravenscroft G."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/author | "Clement S."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/author | "Nowak K.J."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/author | "Walker K.R."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/author | "Fabian V.A."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/author | "Colley S.M."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/author | "Lipscombe R."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/name | "Neuromuscul Disord"xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/pages | "953-958"xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/title | "Expression of cardiac alpha-actin spares extraocular muscles in skeletal muscle alpha-actin diseases--quantification of striated alpha-actins by MRM-mass spectrometry."xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/18952430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18952430 |
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