| http://purl.uniprot.org/citations/18953287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18953287 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent advances in understanding beta-catenin-independent WNT (non-canonical) signalling suggest an increasing complexity, raising the question of how individual non-canonical pathways are induced and regulated. Here, we examine whether intracellular signalling components such as beta-arrestin (beta-arr) and casein kinases 1 and 2 (CK1 and CK2) can contribute to determining signalling specificity in beta-catenin-independent WNT signalling to the small GTPase RAC-1. Our findings indicate that beta-arr is sufficient and required for WNT/RAC-1 signalling, and that casein kinases act as a switch that prevents the activation of RAC-1 and promotes other non-canonical WNT pathways through the phosphorylation of dishevelled (DVL, xDSH in Xenopus). Thus, our results indicate that the balance between beta-arr and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated."xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2008.193"xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/author | "Bryja V."xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/author | "Schambony A."xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/author | "Schulte G."xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/author | "Cajanek L."xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/author | "Dominguez I."xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/author | "Arenas E."xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/pages | "1244-1250"xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/title | "Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways."xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/18953287 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18953287 |
| http://purl.uniprot.org/citations/18953287 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18953287 |
| http://purl.uniprot.org/uniprot/#_Q3UBT6-mappedCitation-18953287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18953287 |
| http://purl.uniprot.org/uniprot/#_Q60737-mappedCitation-18953287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18953287 |
| http://purl.uniprot.org/uniprot/#_Q61177-mappedCitation-18953287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18953287 |
| http://purl.uniprot.org/uniprot/#_Q3USK2-mappedCitation-18953287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18953287 |
| http://purl.uniprot.org/uniprot/#_Q9DC28-mappedCitation-18953287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18953287 |
| http://purl.uniprot.org/uniprot/#_Q6NSS6-mappedCitation-18953287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18953287 |
| http://purl.uniprot.org/uniprot/#_Q8CD20-mappedCitation-18953287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18953287 |
| http://purl.uniprot.org/uniprot/#_Q9D0E8-mappedCitation-18953287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18953287 |
| http://purl.uniprot.org/uniprot/Q9DC28 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18953287 |