| http://purl.uniprot.org/citations/18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18955045 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular retinoic acid binding protein II (CRABP-II) is overexpressed in a wide variety of cancers. Previously we have shown that CRABP-II expression levels are also elevated in neuroblastoma and Wilms tumors. To elucidate the molecular mechanisms underlying the abnormal expression of CRABP-II in Wilms tumor, we studied the expression of MycN and CRABP-II in these tumor samples. Our data revealed that CRABP-II is overexpressed in Wilms tumor compared to normal adjacent non-neoplastic tissue and its levels are even higher in late stage tumors. Its expression correlates with MycN expression in tumors. The tumors that do not express MycN have no CRABP-II expression. The expression of CRABP-II is also regulated by methylation and its promoter is unmethylated in tumors. Knockdown of MycN by small interfering RNA leads to downregulation of CRABP-II. Thus our results suggest that both MycN and DNA methylation are responsible for CRABP-II expression in pediatric tumors and demethylation of CRABP-II may be an early event in tumor development."xsd:string |
| http://purl.uniprot.org/citations/18955045 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2008.09.029"xsd:string |
| http://purl.uniprot.org/citations/18955045 | http://purl.uniprot.org/core/author | "Kessler P."xsd:string |
| http://purl.uniprot.org/citations/18955045 | http://purl.uniprot.org/core/author | "Gupta A."xsd:string |
| http://purl.uniprot.org/citations/18955045 | http://purl.uniprot.org/core/author | "Williams B.R."xsd:string |
| http://purl.uniprot.org/citations/18955045 | http://purl.uniprot.org/core/author | "Rawwas J."xsd:string |
| http://purl.uniprot.org/citations/18955045 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18955045 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/18955045 | http://purl.uniprot.org/core/pages | "3663-3668"xsd:string |
| http://purl.uniprot.org/citations/18955045 | http://purl.uniprot.org/core/title | "Regulation of CRABP-II expression by MycN in Wilms tumor."xsd:string |
| http://purl.uniprot.org/citations/18955045 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/18955045 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18955045 |
| http://purl.uniprot.org/citations/18955045 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18955045 |
| http://purl.uniprot.org/uniprot/#_A0A166VE84-mappedCitation-18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18955045 |
| http://purl.uniprot.org/uniprot/#_A0A1W2PPD9-mappedCitation-18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18955045 |
| http://purl.uniprot.org/uniprot/#_B4DRZ1-mappedCitation-18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18955045 |
| http://purl.uniprot.org/uniprot/#_B4DP83-mappedCitation-18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18955045 |
| http://purl.uniprot.org/uniprot/#_P04198-mappedCitation-18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18955045 |
| http://purl.uniprot.org/uniprot/#_P29373-mappedCitation-18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18955045 |
| http://purl.uniprot.org/uniprot/#_Q7Z7Q9-mappedCitation-18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18955045 |
| http://purl.uniprot.org/uniprot/#_Q9UMQ5-mappedCitation-18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18955045 |
| http://purl.uniprot.org/uniprot/#_Q9H224-mappedCitation-18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18955045 |
| http://purl.uniprot.org/uniprot/#_V9H1L1-mappedCitation-18955045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18955045 |
| http://purl.uniprot.org/uniprot/A0A166VE84 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18955045 |