| http://purl.uniprot.org/citations/18955553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18955553 | http://www.w3.org/2000/01/rdf-schema#comment | "The blood-brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and maintenance of BBB characteristics during embryonic and postnatal development. Endothelial specific stabilization of beta-cat in vivo enhances barrier maturation, whereas inactivation of beta-cat causes significant down-regulation of claudin3 (Cldn3), up-regulation of plamalemma vesicle-associated protein, and BBB breakdown. Stabilization of beta-cat in primary brain endothelial cells (ECs) in vitro by N-terminal truncation or Wnt3a treatment increases Cldn3 expression, BBB-type tight junction formation, and a BBB characteristic gene signature. Loss of beta-cat or inhibition of its signaling abrogates this effect. Furthermore, stabilization of beta-cat also increased Cldn3 and barrier properties in nonbrain-derived ECs. These findings may open new therapeutic avenues to modulate endothelial barrier function and to limit the devastating effects of BBB breakdown."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200806024"xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Reis M."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Liebner S."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Taketo M.M."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Fruttiger M."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Taddei A."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Felici A."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Gerhardt H."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Wolburg H."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Corada M."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Dejana E."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "von Melchner H."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Plate K.H."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Bangsow T."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Babbage J."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/author | "Czupalla C.J."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/pages | "409-417"xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/title | "Wnt/beta-catenin signaling controls development of the blood-brain barrier."xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/18955553 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18955553 |
| http://purl.uniprot.org/citations/18955553 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18955553 |