| http://purl.uniprot.org/citations/18957513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18957513 | http://www.w3.org/2000/01/rdf-schema#comment | "The vascular endothelium is a crucial interface that controls the recruitment of circulating leukocytes. Based on the luminal expression of the ephrin-B2 ligand by endothelial cells (ECs) and the expression of EphB receptors (EphBRs) by circulating monocytes, we hypothesized that EphBR-ephrinB interactions are involved in monocyte adhesion. Adhesion experiments with monocytic cells were performed on ECs that overexpressed either full-length ephrin-B2 or cytoplasmically truncated ephrin-B2 (DeltaC-ephrin-B2). Atomic force microscopy confirmed similar adhesive strengths of EphBR-expressing J774 cells to ECs that either overexpressed full-length ephrin-B2 or truncated DeltaC-ephrin-B2 (1-minute interaction). Yet, adhesion experiments under static or flow conditions for 30 minutes demonstrated the preferential adhesion of monocytic cells to ECs that overexpressed full-length ephrin-B2 but not to DeltaC-ephrin-B2 or to ECs that had been mock transduced. Adhesion was blocked by ephrin-B2-specific and EphBR-specific antibodies. Correspondingly, adhesion of EphB4-receptor-overexpressing monocytes to ephrin-B2-positive ECs was further augmented. Trafficking experiments of cell-surface molecules revealed that, prior to internalization, the resulting EphB4-receptor-ephrin-B2 complex translocated from the luminal surface to inter-endothelial junctions. Lastly, full-length ephrin-B2 in ECs was also involved in monocyte transmigration. Collectively, our study identifies a role of EphBR-ephrinB interactions as a new step in the cascade of events leading to monocyte adhesion and transmigration through the vascular endothelium."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.030627"xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/author | "Hecker M."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/author | "Ludwig T."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/author | "Augustin H.G."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/author | "Reiss Y."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/author | "Pfaff D."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/author | "Heroult M."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/author | "Korff T."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/author | "Riedel M."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/author | "Kirmse R."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/pages | "3842-3850"xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/title | "Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes."xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/18957513 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18957513 |
| http://purl.uniprot.org/citations/18957513 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18957513 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQW9-mappedCitation-18957513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18957513 |
| http://purl.uniprot.org/uniprot/#_P52799-mappedCitation-18957513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18957513 |
| http://purl.uniprot.org/uniprot/#_P52800-mappedCitation-18957513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18957513 |
| http://purl.uniprot.org/uniprot/#_E2I6F7-mappedCitation-18957513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18957513 |
| http://purl.uniprot.org/uniprot/#_B4DQP7-mappedCitation-18957513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18957513 |
| http://purl.uniprot.org/uniprot/#_B4DSE0-mappedCitation-18957513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18957513 |