| http://purl.uniprot.org/citations/18957723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18957723 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of Human Neutrophil Peptides (HNP) 1-3 was recently found to be associated with development of colorectal cancer. Raised defensin-expression in tumours is believed to stem from increased infiltration of neutrophils into tumour environment. To further specify the role of alpha-defensins in tumourigenesis and progression, HNP1-3 were analyzed in colorectal adenomas and carcinomas of 87 patients and quantified in relation to cancer stage and grading. Using the ProteinChip arrays, HNP1-3 were found upregulated in both colorectal adenomas and carcinomas. By combining the array with Laser capture microscopy we were able to confirm that HNP1-3 are expressed by tumour cells but not by neutrophils or other tumour invading cells. These findings suggest that alpha-defensins are more likely to contribute to tumour growth than they are to mount an effective host anti-tumour response. However, the amount of HNP-expression was not found to be related to tumour stage, grading, and serological tumour markers."xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.org/dc/terms/identifier | "doi:10.1155/2008/693937"xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/author | "von Eggeling F."xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/author | "Kaufmann R."xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/author | "Ernst G."xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/author | "Mothes H."xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/author | "Settmacher U."xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/author | "Melle C."xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/name | "Dis Markers"xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/pages | "123-129"xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/title | "Human Neutrophil Peptides 1-3--early markers in development of colorectal adenomas and carcinomas."xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/18957723 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18957723 |
| http://purl.uniprot.org/citations/18957723 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18957723 |
| http://purl.uniprot.org/uniprot/#_Q6EZE9-mappedCitation-18957723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18957723 |
| http://purl.uniprot.org/uniprot/#_P59665-mappedCitation-18957723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18957723 |
| http://purl.uniprot.org/uniprot/#_P59666-mappedCitation-18957723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18957723 |
| http://purl.uniprot.org/uniprot/P59666 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18957723 |
| http://purl.uniprot.org/uniprot/Q6EZE9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18957723 |
| http://purl.uniprot.org/uniprot/P59665 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18957723 |