| http://purl.uniprot.org/citations/18958159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18958159 | http://www.w3.org/2000/01/rdf-schema#comment | "Salmonella is an intracellular bacterial pathogen that replicates within a membrane-bound vacuole in host cells. The major lysosomal membrane proteins 1 and 2 (LAMP-1 and LAMP-2) are recruited to the Salmonella-containing vacuole as well as Salmonella-associated filaments (Sifs) that emerge from the vacuole. LAMP-1 is a dominant membrane marker for the vacuole and Sifs. Its colocalization with both is dependent on a major secreted bacterial virulence protein, SifA. Here, we show that SifA is required for the recruitment of LAMP-2 and can be used as a second independent marker for both the bacterial vacuolar membrane and Sifs. Further, RNAi studies revealed that in LAMP-1 depleted cells, the bacteria remain membrane bound as measured by their association with LAMP-2 protein. In contrast, LAMP-2 depletion increased the amount of LAMP-1 free bacteria. Together, the data suggests that despite its abundance, LAMP-1 is not essential, but LAMP-2 may be partially important for the Salmonella-containing vacuolar membrane."xsd:string |
| http://purl.uniprot.org/citations/18958159 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0003538"xsd:string |
| http://purl.uniprot.org/citations/18958159 | http://purl.uniprot.org/core/author | "Haldar K."xsd:string |
| http://purl.uniprot.org/citations/18958159 | http://purl.uniprot.org/core/author | "Roark E.A."xsd:string |
| http://purl.uniprot.org/citations/18958159 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18958159 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/18958159 | http://purl.uniprot.org/core/pages | "e3538"xsd:string |
| http://purl.uniprot.org/citations/18958159 | http://purl.uniprot.org/core/title | "Effects of lysosomal membrane protein depletion on the Salmonella-containing vacuole."xsd:string |
| http://purl.uniprot.org/citations/18958159 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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| http://purl.uniprot.org/uniprot/B7Z2R9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18958159 |
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