Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/18958543http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18958543http://www.w3.org/2000/01/rdf-schema#comment"

Background

Matrix metalloproteinases (MMPs) are a family of enzymes that degrade most macromolecules making up the extracellular matrix. MMPs are involved in not only the gastric mucosal inflammatory response but also the pathogenesis of Helicobacter pylori-associated diseases. In the renin-angiotensin system, chymase (CMA) is related to gastric carcinogenesis and angiogenesis in H. pylori-infected patients. We aimed to clarify the association of MMP-7-181 and CMA/B polymorphisms with susceptibility to gastric cancer and cancer progression in H. pylori-infected patients.

Methods

We assessed the MMP-7-181 and CMA/B polymorphisms in H. pylori-positive patients with gastric cancer (n = 160), gastric ulcer (n = 157), duodenal ulcer (n = 121), and H. pylori-positive gastritis alone as controls (n = 156).

Results

For gastric cancer risk, the age-and sex-adjusted odds ratio (OR) of the MMP-7-181 G allele carrier relative to the A/A genotype was significantly increased [OR, 2.32; 95% confidence interval (CI), 1.24-4.35], especially in patients with noncardia cancer (OR, 2.31; 95% CI, 1.22-4.36) and those with clinical stage III or IV cancer (OR, 3.66; 95% CI, 1.54-8.73). Carriage of the CMA/B A allele was significantly associated with gastric cancer development (OR, 1.73; 95% CI, 1.10-2.71). Simultaneous carriage of both the MMP-7-181 G allele and the CMA/B A allele dramatically increased the gastric cancer risk (OR, 8.18; 95% CI, 2.79-23.93).

Conclusions

In Japan, carriage of the MMP-7-181 G allele and of the CMA/B A allele were each associated with an increased risk for H. pylori-related noncardia gastric cancer development. MMP-7-181 and CMA/B genotyping tests might be useful tools for screening for individuals with higher gastric cancer risk."xsd:string
http://purl.uniprot.org/citations/18958543http://purl.org/dc/terms/identifier"doi:10.1007/s00535-008-2221-6"xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/author"Sugimoto M."xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/author"Furuta T."xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/author"Hishida A."xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/author"Nishino M."xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/author"Ikuma M."xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/author"Sugimura H."xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/author"Yamade M."xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/author"Kodaira C."xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/name"J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/pages"751-761"xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/title"Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan."xsd:string
http://purl.uniprot.org/citations/18958543http://purl.uniprot.org/core/volume"43"xsd:string
http://purl.uniprot.org/citations/18958543http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18958543
http://purl.uniprot.org/citations/18958543http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18958543
http://purl.uniprot.org/uniprot/#_A5GZ72-mappedCitation-18958543http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18958543
http://purl.uniprot.org/uniprot/#_B4DDW4-mappedCitation-18958543http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18958543
http://purl.uniprot.org/uniprot/#_Q53GF1-mappedCitation-18958543http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18958543
http://purl.uniprot.org/uniprot/#_P23946-mappedCitation-18958543http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18958543
http://purl.uniprot.org/uniprot/#_P09237-mappedCitation-18958543http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18958543
http://purl.uniprot.org/uniprot/#_Q4FEB3-mappedCitation-18958543http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18958543
http://purl.uniprot.org/uniprot/#_Q4FEB5-mappedCitation-18958543http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18958543
▶